Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.

  title={Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.},
  author={Zhifeng Zhou and Camilla Karlsson and Tiebing Liang and Wei Xiong and Mitsuru Kimura and Jenica D. Tapocik and Qiaoping Yuan and Estelle Barbier and Austin Y Feng and Meghan E Flanigan and Eric Augier and M. E. Sharmini Enoch and Colin Hodgkinson and Pei-Hong Shen and David M. Lovinger and Howard J. Edenberg and Markus Heilig and David Goldman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 42},
Identification of genes influencing complex traits is hampered by genetic heterogeneity, the modest effect size of many alleles, and the likely involvement of rare and uncommon alleles. Etiologic complexity can be simplified in model organisms. By genomic sequencing, linkage analysis, and functional validation, we identified that genetic variation of Grm2, which encodes metabotropic glutamate receptor 2 (mGluR2), alters alcohol preference in animal models. Selectively bred alcohol-preferring (P… CONTINUE READING
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