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Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

The findings suggest that MDMA is toxic to serotonergic and, to a lesser extent, catecholaminergic neurons and some neurons that do not contain these transmitters (neocortical neurons) are also affected.
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Effects of clomipramine on self-control choice in Lewis and Fischer 344 rats

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Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys.

It is suggested that stimulation of either D1 or D2 receptors is necessary but not sufficient for the expression of the discriminative stimulus effects of cocaine and that blockade of dopamine re-uptake is sufficient to mimic the cocaine discrim inative stimulus.
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In Vivo Effects of Amphetamine Analogs Reveal Evidence for Serotonergic Inhibition of Mesolimbic Dopamine Transmission in the Rat

The findings are consistent with the hypothesis that 5-HT release dampens stimulant effects of amphetamine-type drugs, but further studies are required to address the precise mechanisms underlying this phenomenon.
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Neurobiology of cocaine abuse.

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Behavioral and Neurochemical Consequences of Long-Term Intravenous Self-Administration of MDMA and Its Enantiomers by Rhesus Monkeys

The reinforcing effects of MDMA are selectively attenuated by chronic MDMA self-administration, although this behavioral change appears to occur in the absence of any frank neurochemical correlates of toxicity.
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Effect of Aripiprazole, a Partial Dopamine D2 Receptor Agonist, on Increased Rate of Methamphetamine Self-Administration in Rats with Prolonged Session Duration

The present data suggest increased sensitivity of the dopaminergic system to aripiprazole in LgA rats compared with ShA rats, however, mechanisms other than downregulation of D2 DA receptors in the nucleus accumbens and the striatum may be responsible for the increasedsensitive function.
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Estimating the relative reinforcing strength of (±)-3,4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine

Self-administration of MA, MDMA, and its isomers using a progressive-ratio schedule in rhesus monkeys supported the hypothesis that increasing 5-HT releasing potency relative to DA is associated with weaker reinforcing effects.
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Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys

This experiment demonstrates that the choice between cocaine and a non-drug or drug alternative can be modified by increasing the interval between behavior and drug injection, consistent with a temporal discounting model of drug choice.
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Long-term effects of chronic methamphetamine administration in rhesus monkeys

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