• Publications
  • Influence
Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.
The findings suggest that MDMA is toxic to serotonergic and, to a lesser extent, catecholaminergic neurons and some neurons that do not contain these transmitters (neocortical neurons) are also affected.
Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys.
It is suggested that stimulation of either D1 or D2 receptors is necessary but not sufficient for the expression of the discriminative stimulus effects of cocaine and that blockade of dopamine re-uptake is sufficient to mimic the cocaine discrim inative stimulus.
Effects of clomipramine on self-control choice in Lewis and Fischer 344 rats
The present findings suggest that differences in delay discounting/impulsive choice may involve genetic, e.g., neurochemical, differences.
Behavioral and Neurochemical Consequences of Long-Term Intravenous Self-Administration of MDMA and Its Enantiomers by Rhesus Monkeys
The reinforcing effects of MDMA are selectively attenuated by chronic MDMA self-administration, although this behavioral change appears to occur in the absence of any frank neurochemical correlates of toxicity.
Estimating the relative reinforcing strength of (±)-3,4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine
Self-administration of MA, MDMA, and its isomers using a progressive-ratio schedule in rhesus monkeys supported the hypothesis that increasing 5-HT releasing potency relative to DA is associated with weaker reinforcing effects.
Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites and behavior in rhesus monkey
It is suggested that the caudate nucleus may be more sensitive than other dopamine-containing brain regions to long-lasting pre- and post-synaptic effects of repeated cocaine administration, and that the changes seen in dopaminergic neurons may be related to behavioral sensitization.
In Vivo Effects of Amphetamine Analogs Reveal Evidence for Serotonergic Inhibition of Mesolimbic Dopamine Transmission in the Rat
The findings are consistent with the hypothesis that 5-HT release dampens stimulant effects of amphetamine-type drugs, but further studies are required to address the precise mechanisms underlying this phenomenon.
Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys
This experiment demonstrates that the choice between cocaine and a non-drug or drug alternative can be modified by increasing the interval between behavior and drug injection, consistent with a temporal discounting model of drug choice.
A novel choice method for studying drugs as punishers
  • W. Woolverton
  • Medicine, Psychology
    Pharmacology Biochemistry and Behavior
  • 1 August 2003
Choice may be a sensitive and selective method for studying aversive effects of drugs in monkeys and effective doses of histamine were approximately 10-fold lower than in previously published experiments.
Neurobiology of cocaine abuse.
Bill Woolverton and Ken Johnson stress that continued collaboration between behavioral pharmacologists and neuroscientists is critical for a complete understanding of the effects of cocaine.