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MHC2TA protein, human

Known as: Class II Transactivator, MHC Class II Transactivator, CIITA 
MHC class II transactivator (1130 aa, ~123 kDa) is encoded by the human CIITA gene. This protein plays a role in the expression of HLA class II genes… 
National Institutes of Health

Related topics

Related topics

8 relations
Antigen PresentationCIITA geneCIITA wt AlleleCell Nucleus

Broader (1)

MHC class II transactivator protein

Papers overview

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Highly Cited
2010
Highly Cited
2010
Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance
Medullary thymic epithelial cells (mTECs) serve an essential function in central tolerance by expressing peripheral-tissue… 
Review
2005
Review
2005
CATERPILLER: a novel gene family important in immunity, cell death, and diseases.
The newly discovered CATERPILLER (CLR) gene family encodes proteins with a variable but limited number of N-terminal domains… 
Highly Cited
2004
Highly Cited
2004
Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
Actin is abundant in the nucleus and has been implicated in transcription; however, the nature of this involvement has not been… 
Review
2001
Review
2001
The bare lymphocyte syndrome and the regulation of MHC expression.
The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the absence of major histocompatibility… 
Highly Cited
1999
Highly Cited
1999
Class II transactivator and class II MHC gene expression in microglia: modulation by the cytokines TGF‐β, IL‐4, IL‐13 and IL‐10
Microglia are the resident macrophages of the brain, and when activated, have functions including cytokine production… 
Highly Cited
1999
Highly Cited
1999
Two Distinct Gamma Interferon-Inducible Promoters of the Major Histocompatibility Complex Class II Transactivator Gene Are Differentially Regulated by STAT1, Interferon Regulatory Factor 1, and…
ABSTRACT The major histocompatibility complex (MHC) class II transactivator (CIITA) is the master regulatory factor required for… 
Highly Cited
1998
Highly Cited
1998
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
Major histocompatibility class II (MHC-II) molecules are transmembrane proteins that have a central role in development and… 
Review
1996
Review
1996
Regulation of MHC class II genes: lessons from a disease.
Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of… 
Highly Cited
1995
Highly Cited
1995
Class II transactivator regulates the expression of multiple genes involved in antigen presentation
CIITA (a major histocompatibility complex [MHC] class II transactivator) has been shown to be required for the expression of MHC… 
Highly Cited
1994
Highly Cited
1994
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes
The class II transactivator (CIITA) has been shown to be required for major histocompatibility complex (MHC) class II gene… 
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