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Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA
The highly complex pattern of expression of major histocompatibility complex class II (MHC‐II) molecules determines both the immune repertoire during development and subsequently the triggering and… Expand
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
Hereditary major histocompatibility complex (MHC) class II deficiency (or bare lymphocyte syndrome) is a form of severe primary immunodeficiency with a total lack of MHC class II expression. It is… Expand
The bare lymphocyte syndrome and the regulation of MHC expression.
The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the absence of major histocompatibility complex class II (MHCII) expression. Considering the central role of MHCII… Expand
Regulation of MHC class II genes: lessons from a disease.
Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the… Expand
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.
- V. Steimle, C. Siegrist, A. Mottet, B. Lisowska-Grospierre, B. Mach
- Biology, Medicine
- 1 July 1994
Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-gamma… Expand
Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1.
CIITA is the mediator of MHC class II gene induction by interferon-gamma (IFNgamma). The CIITA gene is itself selectively activated via one of its four promoters (PIV). We show here that three… Expand
Nomenclature for factors of the HLA system, 2010
The WHO Nomenclature Committee for Factors of the HLA System met following the 14th International HLA and Immunogenetics Workshop in Melbourne, Australia in December 2005 and Buzios, Brazil during… Expand
RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.
Until recently, the RFX family of DNA binding proteins consisted exclusively of four mammalian members (RFX1-RFX4) characterized by a novel highly conserved DNA binding domain. Strong conservation of… Expand
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
Major histocompatibility class II (MHC-II) molecules are transmembrane proteins that have a central role in development and control of the immune system. They are encoded by a multi-gene family and… Expand
A Human Endogenous Retroviral Superantigen as Candidate Autoimmune Gene in Type I Diabetes
- B. Conrad, R. N. Weissmahr, J. Böni, R. Arcari, J. Schüpbach, B. Mach
- Biology, Medicine
- 25 July 1997
Microbial superantigens (SAGs) have been implicated in the pathogenesis of human autoimmune diseases. Preferential expansion of the Vveta7 T cell receptor positive T cell subset in patients suffering… Expand