R. Flavell

Publications1,604
h-index232
Citations207,162
Highly Influential Citations7,952
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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
TLDR
It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs). Expand
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
TLDR
In mammals, BH3 domain-only molecules activate multidomain proapoptotic members to trigger a mitochondrial pathway, which both releases cytochrome c to activate caspases and initiates caspase-independent mitochondrial dysfunction. Expand
Inflammasomes in health and disease
TLDR
The functions of the different inflammasome complexes are reviewed and how aberrations in them are implicated in the pathogenesis of human diseases are discussed. Expand
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
TLDR
It is shown that mda-5 is the dominant receptor mediating type I IFN secretion in response to polyI:C in vitro and in vivo, and selectively impaired antiviral response to encephalomyocarditis picornavirus is exhibited, indicating functional specialization of mda -5 in vivo. Expand
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
TLDR
It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses. Expand
Transforming growth factor-beta regulation of immune responses.
TLDR
This review highlights the findings that have advanced the understanding of TGF-beta in the immune system and in disease. Expand
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
TLDR
In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells, indicating that Gata-3 is necessary and sufficient for Th2inflammatory gene expression. Expand
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
TLDR
It is shown that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod1-deficient mice, providing a possible mechanism for Nod 2 mutations in CD. Expand
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
TLDR
It is shown that deficiency of NLRP6 in mouse colonic epithelial cells results in reduced IL-18 levels and altered fecal microbiota characterized by expanded representation of the bacterial phyla Bacteroidetes (Prevotellaceae) and TM7. Expand
MAP kinases in the immune response.
TLDR
Recent progress in understanding the function and regulation of MAP kinase pathways in these phases of immune responses in mammalian species is summarized. Expand
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