Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
Inflammasomes in health and disease
The functions of the different inflammasome complexes are reviewed and how aberrations in them are implicated in the pathogenesis of human diseases are discussed.
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
- Leonid Gitlin, W. Barchet, M. Colonna
- BiologyProceedings of the National Academy of Sciences…
- 30 May 2006
It is shown that mda-5 is the dominant receptor mediating type I IFN secretion in response to polyI:C in vitro and in vivo, and selectively impaired antiviral response to encephalomyocarditis picornavirus is exhibited, indicating functional specialization of mda -5 in vivo.
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Altered interactions between the gut microbiota and the host, produced by defective NLRP3 and NLRP6 inflammasome sensing, may govern the rate of progression of multiple metabolic syndrome-associated abnormalities, highlighting the central role of the microbiota in the pathogenesis of heretofore seemingly unrelated systemic auto-inflammatory and metabolic disorders.
Transforming growth factor-beta regulation of immune responses.
- Ming O. Li, Y. Wan, S. Sanjabi, A. Robertson, R. Flavell
- Biology, MedicineAnnual Review of Immunology
- 21 March 2006
This review highlights the findings that have advanced the understanding of TGF-beta in the immune system and in disease.
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
- Tian Wang, T. Town, L. Alexopoulou, John F Anderson, E. Fikrig, R. Flavell
- Biology, MedicineNature Network Boston
- 1 December 2004
Tlr3-deficient mice were more resistant to lethal WNV infection and had impaired cytokine production and enhanced viral load in the periphery, whereas in the brain, viral load, inflammatory responses and neuropathology were reduced compared to wild-type mice.