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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
- L. Alexopoulou, Agnieszka Czopik Holt, R. Medzhitov, R. Flavell
- Biology, Medicine
- 18 October 2001
It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs). Expand
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
In mammals, BH3 domain-only molecules activate multidomain proapoptotic members to trigger a mitochondrial pathway, which both releases cytochrome c to activate caspases and initiates caspase-independent mitochondrial dysfunction. Expand
Inflammasomes in health and disease
The functions of the different inflammasome complexes are reviewed and how aberrations in them are implicated in the pathogenesis of human diseases are discussed. Expand
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
- Leonid Gitlin, W. Barchet, +5 authors M. Colonna
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 30 May 2006
It is shown that mda-5 is the dominant receptor mediating type I IFN secretion in response to polyI:C in vitro and in vivo, and selectively impaired antiviral response to encephalomyocarditis picornavirus is exhibited, indicating functional specialization of mda -5 in vivo. Expand
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses. Expand
Transforming growth factor-beta regulation of immune responses.
- M. Li, Y. Wan, S. Sanjabi, A. Robertson, R. Flavell
- Biology, Medicine
- Annual review of immunology
- 21 March 2006
This review highlights the findings that have advanced the understanding of TGF-beta in the immune system and in disease. Expand
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells, indicating that Gata-3 is necessary and sufficient for Th2inflammatory gene expression. Expand
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
It is shown that protective immunity mediated by Nod2 recognition of bacterial muramyl dipeptide is abolished in Nod1-deficient mice, providing a possible mechanism for Nod 2 mutations in CD. Expand
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
It is shown that deficiency of NLRP6 in mouse colonic epithelial cells results in reduced IL-18 levels and altered fecal microbiota characterized by expanded representation of the bacterial phyla Bacteroidetes (Prevotellaceae) and TM7. Expand