Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

@article{Hinterberger2010AutonomousRO,
  title={Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance},
  author={Maria Hinterberger and Martin Aichinger and Olivia Prazeres da Costa and David Voehringer and Reinhard W. Hoffmann and Ludger Klein},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={512-519}
}
Medullary thymic epithelial cells (mTECs) serve an essential function in central tolerance by expressing peripheral-tissue antigens. These antigens may be transferred to and presented by dendritic cells (DCs). Therefore, it is unclear whether mTECs, in addition to being an antigen reservoir, also serve a mandatory function as antigen-presenting cells. Here we diminished major histocompatibility complex (MHC) class II on mTECs through transgenic expression of a 'designer' microRNA specific for… 
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