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MAP3K5 protein, human

Known as: MAP/ERK Kinase Kinase 5, mitogen-activated protein kinase kinase kinase 5, human, MEK Kinase 5 
Mitogen-activated protein kinase kinase kinase 5 (1374 aa, ~155 kDa) is encoded by the human MAP3K5 gene. This protein is involved in the apoptosis… 
National Institutes of Health

Related topics

Related topics

22 relations
Apoptosis PromoterCytoplasmEndoplasmic ReticulumEnzyme Gene

Broader (1)

MAP Kinase Kinase Kinase 5

Papers overview

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Highly Cited
2014
Highly Cited
2014
Atmospheric gas plasma–induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis
Atmospheric gas plasmas (AGPs) up-regulate intracellular ROS levels and induce apoptosis in melanoma cells. Evidence for TNF… 
Review
2010
Review
2010
Dual Role of Heat Shock Proteins as Regulators of Apoptosis and Innate Immunity
Stress or heat shock proteins (HSPs) 70 and 90 are powerful chaperones whose expression is induced in response to a wide variety… 
Highly Cited
2007
Highly Cited
2007
Inhibition of Apoptosis-Regulated Signaling Kinase-1 and Prevention of Congestive Heart Failure by Estrogen
Background— Epidemiological studies have shown gender differences in the incidence of congestive heart failure (CHF); however… 
Highly Cited
2006
Highly Cited
2006
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells
Pancreatic adenocarcinoma is an aggressive human malignancy and is characterized by resistance to apoptosis. Recently, NADPH… 
Highly Cited
2004
Highly Cited
2004
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.
Therapeutic strategies aimed at the inhibition of specific cell death mechanisms may increase islet yield and improve cell… 
Highly Cited
2004
Highly Cited
2004
Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity*
Under serum-free conditions, rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), induces a cellular stress response… 
Review
2002
Review
2002
Redox control of cell death.
Cellular redox is controlled by the thioredoxin (Trx) and glutathione (GSH) systems that scavenge harmful intracellular reactive… 
Highly Cited
2002
Highly Cited
2002
Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer
Apoptosis signal‐regulating kinase 1 (ASK1) is a MAPKKK family member which activates c‐Jun N‐terminal kinase (JNK) and p38. In… 
Highly Cited
2001
Highly Cited
2001
Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1*
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that can activate the c-Jun N… 
Highly Cited
2001
Highly Cited
2001
Glutamine-dependent Antiapoptotic Interaction of Human Glutaminyl-tRNA Synthetase with Apoptosis Signal-regulating Kinase 1*
Glutamine has been known to be an apoptosis suppressor, since it blocks apoptosis induced by heat shock, irradiation, and c-Myc… 
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