Skip to search formSkip to main contentSkip to account menu

MAP Kinase Kinase Kinase 5

Known as: MAPK Kinase Kinase 5, Apoptosis Signal Regulating Kinase 1, MAPKKK5 
A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE… 
National Institutes of Health

Related topics

Related topics

10 relations
In BloodMAP3K5 geneProcess of secretionantagonists & inhibitors

Broader (1)

MAP Kinase Kinase Kinase

Narrower (1)

MAP3K5 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis[OPEN]
Multiple pattern-recognition receptors activate mitogen-activated protein kinase cascades and trigger disease resistance in… 
Highly Cited
2012
Highly Cited
2012
Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes
Aims/hypothesisDiabetic cardiomyopathy is characterised by diastolic dysfunction, oxidative stress, fibrosis, apoptosis and… 
Highly Cited
2009
Highly Cited
2009
Oxidizable Residues Mediating Protein Stability and Cytoprotective Interaction of DJ-1 with Apoptosis Signal-regulating Kinase 1*
Parkinson disease (PD)-associated genomic deletions and the destabilizing L166P point mutation lead to loss of the cytoprotective… 
Highly Cited
2006
Highly Cited
2006
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells
Pancreatic adenocarcinoma is an aggressive human malignancy and is characterized by resistance to apoptosis. Recently, NADPH… 
Review
2006
Review
2006
PP2C family members play key roles in regulation of cell survival and apoptosis
Although unlimited proliferation of cancer cells is supported by multiple signaling pathways involved in the regulation of… 
Highly Cited
2003
Highly Cited
2003
Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal‐regulating kinase 1 during seizure‐induced neuronal death
The consequences of activation of tumour necrosis factor receptor 1 (TNFR1) during neuronal injury remain controversial. The… 
Review
2001
Review
2001
Survival-promoting functions of 14-3-3 proteins.
The 14-3-3 proteins are a family of phosphoserine/phosphothreonine-binding molecules that control the function of a wide array of… 
Highly Cited
2000
Highly Cited
2000
Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons
ABSTRACT We have previously shown that nerve growth factor (NGF) withdrawal-induced death requires the activity of the small GTP… 
Highly Cited
1997
Highly Cited
1997
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.
The mouse cDNA for apoptosis signal-regulating kinase 1 (ASK)1 was isolated. The overall amino acid sequence identity between the… 
Highly Cited
1996
Highly Cited
1996
Molecular Cloning and Characterization of a Novel Protein Kinase with a Catalytic Domain Homologous to Mitogen-activated Protein Kinase Kinase Kinase*
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)