MAP Kinase Kinase Kinase 5

Known as: MAPK Kinase Kinase 5, Apoptosis Signal Regulating Kinase 1, MAPKKK5 
A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specificity for MAP KINASE KINASE 3; MAP KINASE KINASE… (More)
National Institutes of Health

Papers overview

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2016
2016
Perception of microbe-associated molecular patterns by host cell surface pattern recognition receptors (PRRs) triggers the… (More)
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Highly Cited
2009
Highly Cited
2009
Parkinson disease (PD)-associated genomic deletions and the destabilizing L166P point mutation lead to loss of the cytoprotective… (More)
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Highly Cited
2007
Highly Cited
2007
Parkinson's disease (PD), a neurodegenerative disorder, causes severe motor impairment due to loss of dopaminergic neurons in… (More)
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Highly Cited
2006
Highly Cited
2006
Pancreatic adenocarcinoma is an aggressive human malignancy and is characterized by resistance to apoptosis. Recently, NADPH… (More)
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Highly Cited
2001
Highly Cited
2001
The Akt family of serine/threonine-directed kinases promotes cellular survival in part by phosphorylating and inhibiting death… (More)
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Review
2001
Review
2001
The 14-3-3 proteins are a family of phosphoserine/phosphothreonine-binding molecules that control the function of a wide array of… (More)
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Highly Cited
2000
Highly Cited
2000
We have previously shown that nerve growth factor (NGF) withdrawal-induced death requires the activity of the small GTP-binding… (More)
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1999
1999
Tumor necrosis factor-α (TNF), a major inflammatory cytokine, generates a wide variety of cellular responses via key cytoplasmic… (More)
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Highly Cited
1998
Highly Cited
1998
The Fas death receptor can activate the Jun NH2-terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx… (More)
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1996
1996
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK… (More)
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