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MAP3K5 protein, human

Known as: MAP/ERK Kinase Kinase 5, mitogen-activated protein kinase kinase kinase 5, human, MEK Kinase 5 
Mitogen-activated protein kinase kinase kinase 5 (1374 aa, ~155 kDa) is encoded by the human MAP3K5 gene. This protein is involved in the apoptosis… 
National Institutes of Health

Related topics

Related topics

22 relations
Apoptosis PromoterCytoplasmEndoplasmic ReticulumEnzyme Gene

Broader (1)

MAP Kinase Kinase Kinase 5

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling.
Parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. It… 
2008
2008
DDTD, an isoflavone derivative, induces cell apoptosis through the reactive oxygen species/apoptosis signal-regulating kinase 1 pathway in human osteosarcoma cells.
Highly Cited
2007
Highly Cited
2007
Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.
The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid… 
Highly Cited
2005
Highly Cited
2005
Signal Pathway of Hypoxia-Inducible Factor-1α Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c… 
2005
2005
Fatty acids liberated from low-density lipoprotein trigger endothelial apoptosis via mitogen-activated protein kinases
Enzymatic modification of low-density lipoprotein (LDL) as it probably occurs in the arterial intima drastically increases its… 
2005
2005
Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1.
Fanconi anemia (FA) is a chromosomal instability disorder characterized by progressive bone marrow failure. Experimental evidence… 
2005
2005
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.
Ca2+/calmodulin-dependent protein kinase (CaMK) is an important downstream target of Ca2+ in the hypertrophic signaling pathways… 
2003
2003
Selenite-induced Survival of HuH7 Hepatoma Cells Involves Activation of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Pathway and Rac1*
Selenium has been shown to sustain the growth of selected human hepatocellular carcinoma cell lines under serum-free conditions… 
2003
2003
c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade.
Cell transformation by growth-promoting oncoproteins renders cells extremely sensitive to apoptosis through an unknown mechanism… 
2001
2001
ASK1 resistant neuroblastoma is deficient in activation of p38 kinase
Apoptosis Signal-regulating Kinase 1 (ASK1) is known to either induce apoptosis or differentiation in various cell lines of… 
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