Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

@article{NietoMiguel2007EndoplasmicRS,
  title={Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.},
  author={Teresa Nieto-Miguel and Rosalba I. Fonteriz and Laura Vay and Consuelo Gajate and Silvia L{\'o}pez-Hern{\'a}ndez and Faustino Mollinedo},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={10368-78}
}
The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid analogue edelfosine accumulates in the ER of solid tumor cells. This ER accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, G(2)-M arrest, depletion of ER-stored Ca(2+), Bax up-regulation and activation, transcriptional factor growth arrest and DNA damage-inducible gene 153 up-regulation, caspase-4 and caspase-8 activation… CONTINUE READING

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