J. Spencer

Publications137
h-index66
Citations15,334
Highly Influential Citations536
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Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.
Human intervention trials have provided evidence for protective effects of various (poly)phenol-rich foods against chronic disease, including cardiovascular disease, neurodegeneration, and cancer.… Expand
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Flavonoids: antioxidants or signalling molecules?
Many studies are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties,… Expand
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MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide
Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage… Expand
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Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels.
Phytochemical-rich foods have been shown to be effective at reversing age-related deficits in memory in both animals and humans. We show that a supplementation with a blueberry diet (2% w/w) for 12… Expand
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Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species
Abstract: Oxidation of l‐3,4‐dihydroxyphenylalanine (l‐DOPA) and dopamine (DA) to generate semiquinones/quinones, oxygen radicals, and other reactive oxygen species may play a role in neuronal cell… Expand
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Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research
In order to establish firm evidence for the health effects of dietary polyphenol consumption, it is essential to have quantitative information regarding their dietary intake. The usefulness of the… Expand
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The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans.
Dietary nitrate is metabolized to nitrite by bacterial flora on the posterior surface of the tongue leading to increased salivary nitrite concentrations. In the acidic environment of the stomach,… Expand
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Neuroinflammation: modulation by flavonoids and mechanisms of action.
Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease.… Expand
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Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance.
  • J. Spencer
  • Psychology, Medicine
  • The Proceedings of the Nutrition Society
  • 1 May 2008
Emerging evidence suggests that dietary-derived flavonoids have the potential to improve human memory and neuro-cognitive performance via their ability to protect vulnerable neurons, enhance existing… Expand
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Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.
Oxidative stress has been associated with neuronal loss in neurodegenerative diseases and during age-associated cognitive decline. Flavonoids have been proposed to play a useful role in protecting… Expand
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