c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade.

@article{Desbiens2003cMycPT,
  title={c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade.},
  author={Katia M Desbiens and R{\'e}na G. Deschesnes and Mireille M. Labrie and Yan Desfoss{\'e}s and Herman Lambert and Jacques Landry and Kerstin Bellmann},
  journal={The Biochemical journal},
  year={2003},
  volume={372 Pt 2},
  pages={631-41}
}
Cell transformation by growth-promoting oncoproteins renders cells extremely sensitive to apoptosis through an unknown mechanism affecting the mitochondrial pathway of apoptosis. We have shown previously that sensitization to apoptosis also correlated with the activation of the stress-activated protein kinase p38. In the present study, we investigated the role of p38 in c-Myc-dependent apoptosis induced by the anticancer agent cisplatin. Cisplatin treatment of Rat1 cells with deregulated… CONTINUE READING