Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells

@article{Mochizuki2006InhibitionON,
  title={Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells},
  author={Toshihiro Mochizuki and Shuichi Furuta and Junji Mitsushita and Wei Hao Shang and Masami Ito and Yuh Yokoo and Maki Yamaura and Satoshi Ishizone and Jun Nakayama and Ayano Konagai and Kinuko Hirose and Kendo Kiyosawa and Tohru Kamata},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3699-3707}
}
Pancreatic adenocarcinoma is an aggressive human malignancy and is characterized by resistance to apoptosis. Recently, NADPH oxidase (Nox) 4-mediated generation of intracellular reactive oxygen species (ROS) was proposed to confer antiapoptotic activity and thus a growth advantage to pancreatic cancer cells. The signaling mechanism by which Nox4 transmits cell survival signals remains unclear. Here, we show that both a flavoprotein inhibitor, diphenylene iodonium (DPI), and small interfering… CONTINUE READING
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