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MAP3K5 gene

Known as: MAP/ERK KINASE KINASE 5, MAP3K5, apoptosis signal regulating kinase 1 
This gene is involved in the MAP kinase signal transduction pathway.
National Institutes of Health

Related topics

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6 relations
MAP Kinase Kinase Kinase 5MAP3K5 protein, humanPhosphorylationPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.
Maternal diabetes in mice induces heart defects similar to those observed in human diabetic pregnancies. Diabetes enhances… 
2013
2013
Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner.
Highly Cited
2012
Highly Cited
2012
Searching for molecular targets in sarcoma.
2011
2011
Role of Bim in diallyl trisulfide‐induced cytotoxicity in human cancer cells
The aim of this study was to investigate the effect of garlic constituent diallyl trisulfide (DATS) on the cell‐death signaling… 
2009
2009
Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation*
Cell survival and death-inducing signals are tightly associated with each other, and the decision as to whether a cell survives… 
2005
2005
Cross-talk between JIP3 and JIP1 during Glucose Deprivation
We have previously observed that glucose deprivation activates the ASK1-MEK-MAPK signal transduction pathway. In the present… 
2005
2005
The shear stress of keeping arteries clear
The force exerted by blood as it flows through the vessels influences the development of atherosclerosis. An understanding of how… 
Highly Cited
2003
Highly Cited
2003
Role of the ASK1-SEK1-JNK1-HIPK1 Signal in Daxx Trafficking and ASK1 Oligomerization*
Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the… 
2003
2003
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities
Diverse stimuli initiate the activation of apoptotic signaling pathways that often causes nuclear DNA fragmentation. Here, we… 
Highly Cited
2001
Highly Cited
2001
A combination of the F-box motif and kelch repeats defines a large Arabidopsis family of F-box proteins
In the sequences released by the Arabidopsis Genome Initiative (AGI), we have discovered a new large gene family (48 genes as of… 
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