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High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease
The clinical and genetic relationships between Alzheimer's disease (AD) and glaucoma remain obscure. The aim of this study was to determine the prevalence of open-angle glaucoma (OAG) in patientsExpand
Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.
PURPOSE Toll-like receptor 4 (TLR4) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands and interacts with heat shock proteins, which are reportedlyExpand
Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons
ABSTRACT We have previously shown that nerve growth factor (NGF) withdrawal-induced death requires the activity of the small GTP-binding protein Cdc42 and that overexpression of an active form ofExpand
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.
PURPOSE To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms in Japanese patients with glaucoma. METHODS The OPTN gene was analyzed inExpand
Cloning and regulation of the vertebrate homologue of lin‐41 that functions as a heterochronic gene in Caenorhabditis elegans
The Caenorhabditis elegans gene lin‐41 is the one of the heterochronic genes that regulate the timing of many developmental events. MicroRNA let‐7 negatively regulates the expression of lin‐41Expand
Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.
Mutations of Filamin genes, which encode actin-binding proteins, cause a wide range of congenital developmental malformations in humans, mainly skeletal abnormalities. However, the molecularExpand
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage.
Inactivation of the BRCA1 gene has been found to confer susceptibility to early-onset familial breast and ovarian cancers. BRCA1 regulates DNA repair, chromatin remodeling and affects geneExpand
Genetic polymorphisms in the angiotensin II receptor gene and their association with open-angle glaucoma in a Japanese population.
PURPOSE The local renin-angiotensin system (RAS) is present in the ciliary body and plays a role in regulating aqueous humor dynamics and thus intraocular pressure (IOP). The purpose of this studyExpand
MRI analysis of single-, double-, and triple-bundle anterior cruciate ligament grafts
PurposeThe purpose of the study was to evaluate the entire course of ACL grafts on coronal oblique MR images, focusing on differences in graft morphology and graft-to-tunnel healing amongExpand
Cloning and expression pattern of lbx3, a novel chick homeobox gene.
The Drosophila melanogaster genes, ladybird early (lbe) and ladybird late (lbl), encode transcriptional regulators, which play an important role in neurogenesis, myogenesis and cardiogenesis. Here,Expand