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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
TLDR
It is shown that oligomers of islet amyloid polypeptide (IAPP), a protein that formsAmyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β. Expand
Adult T-cell leukemia: clinical and hematologic features of 16 cases.
TLDR
Clinical and hematologic studies of 16 adult patients whose leukemic cells had Tcell markers from Japan, where the incidence of various lymphoproliferative diseases differs considerably from that in Western countries, discuss the relation between cases and other subacute or chronic adult T-ceIl malignancies. Expand
Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression*
TLDR
The results suggested that TBP-2/VDUP1 serves as a negative regulator of the biological function and expression of TRX, an important redox regulatory mechanism in cellular processes, including differentiation of myeloid and macrophage lineages. Expand
Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus
TLDR
This in vitro diamide-induced cross-linking study showed that TRX can associate directly with NF-κB p50, and two-step TRX-dependent regulation of the NF-kkB complex may be a novel activation mechanism of redox-sensitive transcription factors. Expand
Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300
TLDR
Transfection analysis using fusion genes of GAL4DBD with various fragments of the two factors delineated two transcription activation domains which are inducible in response to hypoxia and are localized in the C‐terminal half of HIF1α. Expand
Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62.
TLDR
Modification of p50 by thioredoxin, a gene induced by stimulation of T-lymphocytes in parallel with NF-kappa B translocation, is a likely step in the cascade of events leading to full NF- kappa B activation. Expand
Glutaredoxin Exerts an Antiapoptotic Effect by Regulating the Redox State of Akt*
TLDR
Overexpression of GRX protected Akt from H2O2-induced oxidation and suppressed recruitment of protein phosphatase 2A to Akt, resulting in a sustained phosphorylation of Akt and inhibition of apoptosis, and an in vitro assay revealed that GRX reduced oxidized Akt in concert with glutathione, NADPH, and glutathionsulfide reductase. Expand
Persistent oxidative stress in cancer
TLDR
It is suggested that the concept of ‘persistent oxidative stress in cancer’ may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto‐oncogenes, genomic instability, chemotherapy‐resistance, invasion and metastasis. Expand
Redox control of cell death.
TLDR
Mitochondria-specific thioredoxin (Trx-2) and Trx peroxidases (peroxiredoxins) are suggested to regulate cytochrome c release from mitochondria, which is a critical early step in the apoptotis-signaling pathway. Expand
Redox regulation of cellular activation.
TLDR
Adult T cell leukemia-derived factor (ADF), which was originally defined as an IL-2 receptor alpha-chain/Tac inducer produced by human T cell lymphotrophic virus-I (HTLV-I)-transformed T cells, has been identified as human TRX. Expand
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