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MAP kinase kinase kinase activity

Known as: MAPKKK activity, MLTKa, mitogen-activated protein kinase kinase kinase activity 
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (1)

MAP Kinase Cascade
MAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 geneMAP3K1 wt Allele

Narrower (1)

MAP kinase kinase kinase activity involved in osmosensory signaling pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Heme oxygenase-1: from bench to bedside.
As aspects of basic science come to play an increasingly prominent role in clinical medicine, heme oxygenase-1 is one of several… 
Highly Cited
2001
Highly Cited
2001
Akt Down-regulation of p38 Signaling Provides a Novel Mechanism of Vascular Endothelial Growth Factor-mediated Cytoprotection in Endothelial Cells*
Vascular endothelial growth factor (VEGF) utilizes a phosphoinositide 3-kinase (PI 3-kinase)/Akt signaling pathway to protect… 
Highly Cited
1999
Highly Cited
1999
Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways
ABSTRACT A hallmark of inflammation is the burst-like formation of certain proteins, initiated by cellular stress and… 
Highly Cited
1998
Highly Cited
1998
Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two‐component response regulator
Exposure of yeast cells to increased extracellular osmolarity induces the HOG1 mitogen‐activated protein kinase (MAPK) cascade… 
Highly Cited
1998
Highly Cited
1998
Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway*
The mitogen-activated protein kinase (MAPK) cascade is believed to function as an important regulator of prostaglandin… 
Highly Cited
1997
Highly Cited
1997
Reconstitution of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria
Mitogen-activated protein (MAP) kinase pathways include a three-kinase cascade terminating in a MAP kinase family member. The… 
Highly Cited
1997
Highly Cited
1997
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
MEK kinases (MEKKs) 1, 2, 3 and 4 are members of sequential kinase pathways that regulate MAP kinases including c‐Jun NH2… 
Highly Cited
1996
Highly Cited
1996
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
Highly Cited
1996
Highly Cited
1996
A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and…
We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members… 
Highly Cited
1996
Highly Cited
1996
Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway
Certain small GTP-binding proteins control the enzymatic activity of a family of closely related serine-threonine kinases known… 
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