FAQ

MAP kinase kinase kinase activity

Known as: MAPKKK activity, MLTKa, mitogen-activated protein kinase kinase kinase activity 
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2017
0204019742017

Related topics

Related topics

7 relations

Broader (1)

MAP Kinase Cascade
MAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP3K1 geneMAP3K1 wt Allele
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Related mentions per year

Related mentions per year

1974-2018
197019801990200020102020
MAP kinase kinase kinase activity
MAP Kinase Cascade
MAP kinase kinase activity
MAP3K1 gene
MAPK-ERK Kinases
MAP3K1 wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue.
PURPOSE Histopathology is the standard approach for tissue diagnostics and centerpiece of pathology. Although the current system… (More)
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Highly Cited
2008
Highly Cited
2008
MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants
Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant innate immune responses. In a genetic… (More)
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Highly Cited
2006
Highly Cited
2006
A Mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis.
Mitogen-activated protein kinase kinase kinases (MAPKKKs) play key roles in intra- and extracellular signaling in eukaryotes… (More)
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Highly Cited
1999
Highly Cited
1999
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.
Stabilization of mRNAs contributes to the strong and rapid induction of genes in the inflammatory response. The signaling… (More)
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Highly Cited
1997
Highly Cited
1997
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.
MEK kinases (MEKKs) 1, 2, 3 and 4 are members of sequential kinase pathways that regulate MAP kinases including c-Jun NH2… (More)
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Highly Cited
1997
Highly Cited
1997
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
Several members of the tumour-necrosis/nerve-growth factor (TNF/NGF) receptor family activate the transcription factor NF-kappaB… (More)
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1996
1996
Angiotensin II stimulates MAP kinase kinase kinase activity in vascular smooth muscle cells, Role of Raf.
Both angiotensin II (Ang II) and platelet-derived growth factor (PDGF) rapidly increase intracellular Ca2+ and activate protein… (More)
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1996
1996
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation.
The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1, tumor… (More)
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Highly Cited
1994
Highly Cited
1994
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
Growth factors activate mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs) and… (More)
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1993
1993
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.
Plasma membrane-enriched fractions were prepared from human embryonic retinal cells transformed with either adenovirus E1A and… (More)
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