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MAP3K1 wt Allele

Known as: MAPKKK1, MEKK1, Mitogen-Activated Protein Kinase Kinase Kinase 1 wt Allele 
Human MAP3K1 wild-type allele is located in the vicinity of 5q11.2 and is approximately 82 kb in length. This allele, which encodes mitogen-activated… 
National Institutes of Health

Related topics

Related topics

32 relations
5q11.2Angiotensin II Signaling PathwayB Cell Receptor Signaling PathwayCD40L Signaling Pathway

Broader (1)

MAP3K1 gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
Phosphorylation of Arabidopsisthaliana MEKK1 via Ca2+ signaling as a part of the cold stress response
The Arabidopsis mitogen activated protein kinase kinase kinase (MEKK1) plays an important role in stress signaling. However… 
Highly Cited
2008
Highly Cited
2008
TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway*
Type I interferons (IFN-α/β) are essential for immune defense against viruses and induced through the actions of the cytoplasmic… 
Highly Cited
2007
Highly Cited
2007
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
Mice lacking activity of the kinase MEKK1 ('Map3k1ΔKD' mice) have defective activation of the kinase Jnk and increased production… 
Highly Cited
2006
Highly Cited
2006
MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer
Mammary tumor cells are required to degrade the surrounding matrix and disseminate in order to metastasize, and both of these… 
Highly Cited
2004
Highly Cited
2004
Negative Regulation of MEKK1-induced Signaling by Glutathione S-Transferase Mu*
Mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1) is an important component in the… 
Highly Cited
2002
Highly Cited
2002
Dominant negative MEKK1 inhibits survival of pancreatic cancer cells
Human pancreatic cancers harbor mutations in the K-ras gene, and these mutations convert the gene oncogenic and constitutively… 
2002
2002
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.
IFN-gamma induces a number of genes to up-regulate cellular responses by using specific transcription factors and the cognate… 
Highly Cited
2000
Highly Cited
2000
Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation.
NF-kappaB is regulated by inhibitor proteins (IkappaBs), which retain NF-kappaB in the cytoplasm. Signal-induced phosphorylation… 
Highly Cited
1998
Highly Cited
1998
Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway*
The mitogen-activated protein kinase (MAPK) cascade is believed to function as an important regulator of prostaglandin… 
Highly Cited
1996
Highly Cited
1996
Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation (*)
The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1, tumor… 
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