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MAP3K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase Kinase 1 Gene, MAPKKK1, MEK KINASE 
This gene plays a role in mediating cellular responses to growth factors, metabolic stimuli and mitogens.
National Institutes of Health

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MAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP kinase kinase kinase activityMAP3K1 protein, human

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MAP3K1 wt Allele

Papers overview

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2020
2020
Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome
Abstract Androgen insensitivity syndrome (AIS; OMIM 300068) is the most frequent cause of 46, XY disorders of sex development… 
2019
2019
Predictive accuracy of the breast cancer genetic risk model based on eight common genetic variants: The BACkSIDE study.
2018
2018
Genetic Variation in MAP3K1 Associates with Ventilator‐Free Days in Acute Respiratory Distress Syndrome
&NA; Mitogen‐activated protein kinase kinase kinase 1 (MAP3K1) regulates numerous intracellular signaling pathways involved in… 
Review
2018
Review
2018
Disorder of sex development 46,XY associated with mutations in the gene MAP3K1. The report of clinical cases
The disorders of sex development (DSD) 46,XY may be caused by mutations in a number of genes involved in the gonadal… 
2016
2016
Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.
Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from… 
2015
2015
MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1.
AIM To investigate the underlying molecular mechanisms of miR-451 to inhibit proliferation of esophageal carcinoma cell line… 
2012
2012
Rapidly screening variants of uncertain significance in the MAP3K1 gene for phenotypic effects
Loke J, Ostrer H. Rapidly screening variants of uncertain significance in the MAP3K1 gene for phenotypic effects. 
2012
2012
Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
The prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1… 
2010
2010
Familial brain arteriovenous malformation maps to 5p13-q14, 15q11-q13 or 18p11: linkage analysis with clipped fingernail DNA on high-density SNP array.
2003
2003
Comprehensive genome-wide comparison of DNA and RNA level scan using microarray technology for identification of candidate cancer-related genes in the HL-60 cell line.
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