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MAP3K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase Kinase 1 Gene, MAPKKK1, MEK KINASE 
This gene plays a role in mediating cellular responses to growth factors, metabolic stimuli and mitogens.
National Institutes of Health

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MAP Kinase Kinase Kinase 1MAP kinase kinase activityMAP kinase kinase kinase activityMAP3K1 protein, human

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MAP3K1 wt Allele

Papers overview

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2018
2018
Genetic Variation in MAP3K1 Associates with Ventilator‐Free Days in Acute Respiratory Distress Syndrome
&NA; Mitogen‐activated protein kinase kinase kinase 1 (MAP3K1) regulates numerous intracellular signaling pathways involved in… 
Review
2018
Review
2018
Disorder of sex development 46,XY associated with mutations in the gene MAP3K1. The report of clinical cases
The disorders of sex development (DSD) 46,XY may be caused by mutations in a number of genes involved in the gonadal… 
2018
2018
Next-Generation Sequencing Assay Raises New Questions in a Case of Metastatic Prostate Cancer.
A 72-year-old man with a history of prostate cancer presented with metastases to the lung, liver, and bone. He had been initially… 
2017
2017
Abstract S1-10: Clinical implications of somatic mutations in post-menopausal early-stage estrogen receptor (ER)-positive HER2-negative breast cancer (BC): Results from the BIG 1-98 study
Background Next generation sequencing (NGS) has revealed that ER+/HER2- BCs have diverse somatic copy number and mutation… 
2016
2016
Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.
Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from… 
2014
2014
Identification of a Missense MAP3K1 Mutation in a Patient with Hypospadias
1Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Japan , 2 Division of… 
Review
2013
Review
2013
Breast cancer in 2012: New drugs, new knowledge, new targets
In 2012, we increased our knowledge of the molecular portrait of breast cancer. The BOLERO-2 and CLEOPATRA trials led to the… 
2013
2013
Breast Cancer Subtypes and Previously Established Genetic Risk Factors: A Bayesian Approach
Background: Gene expression analyses indicate that breast cancer is a heterogeneous disease with at least five immunohistologic… 
2012
2012
Breast cancer risk factors differ between Asian and white women with BRCA1/2 mutations
The prevalence and penetrance of BRCA1 and BRCA2 (BRCA1/2) mutations may differ between Asians and whites. We investigated BRCA1… 
2010
2010
Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
Recent genome-wide association studies have identified seven single nucleotide polymorphisms (SNPs) associated with breast cancer… 
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