MAP3K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase Kinase 1 Gene, MAPKKK1, MEK KINASE 
This gene plays a role in mediating cellular responses to growth factors, metabolic stimuli and mitogens.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Langerhans cell histiocytosis (LCH) is now understood to be a neoplastic disease in which over 50% of cases have somatic… (More)
Is this relevant?
2015
2015
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of… (More)
  • figure 1
  • table 2
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2014
2014
In-frame missense and splicing mutations (resulting in a 2 amino acid insertion or a 34 amino acid deletion) dispersed through… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2013
2013
Custom TAL effector nucleases (TALENs) are increasingly used as reagents to manipulate genomes in vivo. Here, we used TALENs to… (More)
Is this relevant?
2013
2013
MAP3K1 is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family of serine/threonine kinases. MAP3K1… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Review
2012
Review
2012
Breast cancer (BC) is a heterogeneous disease that exhibits familial aggregation. Family linkage studies have identified high… (More)
  • table 1
  • figure 1
  • table 2
Is this relevant?
2011
2011
In mammals, the Y chromosome is a dominant male determinant, causing the bipotential gonad to develop as a testis. Recently… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2011
2011
Precise coordination of progenitor cell proliferation and differentiation is essential for proper organ morphogenesis and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Investigations of humans with disorders of sex development (DSDs) resulted in the discovery of many of the now-known mammalian… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2007
2007
Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer. We have investigated the… (More)
Is this relevant?