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MAP Kinase Kinase Kinase 1

Known as: MAP3K1 Protein, MEK Kinase 1, MAP Kinase Kinase Kinase 1 [Chemical/Ingredient] 
A 195-kDa zinc finger motif-containing MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It localizes to the CYTOSKELETON and… Expand
National Institutes of Health

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In BloodMAP Kinase Kinase 1MAP kinase kinase kinase activityMAP3K1 gene
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MAP3K1 protein, human

Papers overview

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2013
2013
Mutation analysis of mitogen activated protein kinase 1 gene in Indian cases of 46,XY disorder of sex development
BACKGROUND: Determination of sex is the result of cascade of molecular events that cause undifferentiated bipotential gonad to… Expand
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2011
2011
MEK kinase 1: kinase domain deficiency in mice reveals a role in orchestrating the thymus-dependent immunity and TNFR family signaling.
  • Ewen Gallagher
  • Advances in experimental medicine and biology
  • 2011
    • Corpus ID: 21370651
Almost 20 years ago early work led to the cloning and identification of mitogen-activated protein kinases (MAPKs) as the apical… Expand
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Highly Cited
2009
Highly Cited
2009
Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women.
FGFR2 and MAP3K1 are members of the RAS/RAF/MEK/ERK-signaling pathway and have been identified from genome-wide association… Expand
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2005
2005
D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells
BackgroundThe family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses… Expand
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2002
2002
Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway*
Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has been identified as a member of the mitogen… Expand
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Highly Cited
2001
Highly Cited
2001
The NF-kappaB pathway in human endometrium and first trimester decidua.
Nuclear factor kappa B (NF-kappaB) regulates proinflammatory genes and may be involved in inflammation associated with… Expand
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1998
1998
Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1*
Many growth factors and G protein-coupled receptors activate mitogen-activated protein (MAP) kinase pathways. The MAP kinase… Expand
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1998
1998
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
IkappaB kinases (IKKalpha and IKKbeta) are key components of the IKK complex that mediates activation of the transcription factor… Expand
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1997
1997
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain.
MEK kinase 1 (MEKK1) shares sequence identity with the yeast kinases Ste11 and Byr2, and is capable of phosphorylation and… Expand
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Highly Cited
1996
Highly Cited
1996
Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation (*)
The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1, tumor… Expand
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