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MAP Kinase Kinase Kinase 1

Known as: MAP3K1 Protein, MEK Kinase 1, MAP Kinase Kinase Kinase 1 [Chemical/Ingredient] 
A 195-kDa zinc finger motif-containing MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It localizes to the CYTOSKELETON and… (More)
National Institutes of Health

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1996-2017
02419962017

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In BloodMAP Kinase Kinase 1MAP kinase kinase kinase activityMAP3K1 gene
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MAP3K1 protein, human

Related mentions per year

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1936-2019
19401960198020002020
MAP Kinase Kinase Kinase 1
standards characteristics
physiological aspects
Zinc Fingers
chemical synthesis
MAP kinase kinase kinase activity

Papers overview

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2013
2013
Mutation analysis of mitogen activated protein kinase 1 gene in Indian cases of 46,XY disorder of sex development
BACKGROUND Determination of sex is the result of cascade of molecular events that cause undifferentiated bipotential gonad to… (More)
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Highly Cited
2009
Highly Cited
2009
Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women.
FGFR2 and MAP3K1 are members of the RAS/RAF/MEK/ERK-signaling pathway and have been identified from genome-wide association… (More)
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2008
2008
Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway.
Type I interferons (IFNs) activate Janus tyrosine kinase-signal transducer and activator of transcription pathway for exerting… (More)
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2002
2002
Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway.
Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has been identified as a member of the mitogen… (More)
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2001
2001
The NF-kappaB pathway in human endometrium and first trimester decidua.
Nuclear factor kappa B (NF-kappaB) regulates proinflammatory genes and may be involved in inflammation associated with… (More)
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2001
2001
c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB: role of thioredoxin in NF-kappaB activation.
NF-kappaB is a redox-sensitive transcription factor known to be activated by oxidative stress as well as chemical and biological… (More)
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1998
1998
Regulation of apoptosis by alpha-subunits of G12 and G13 proteins via apoptosis signal-regulating kinase-1.
Many growth factors and G protein-coupled receptors activate mitogen-activated protein (MAP) kinase pathways. The MAP kinase… (More)
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1998
1998
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
IkappaB kinases (IKKalpha and IKKbeta) are key components of the IKK complex that mediates activation of the transcription factor… (More)
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1997
1997
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain.
MEK kinase 1 (MEKK1) shares sequence identity with the yeast kinases Ste11 and Byr2, and is capable of phosphorylation and… (More)
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1996
1996
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation.
The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1, tumor… (More)
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