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MAP Kinase Kinase Kinase 1

Known as: MAP3K1 Protein, MEK Kinase 1, MAP Kinase Kinase Kinase 1 [Chemical/Ingredient] 
A 195-kDa zinc finger motif-containing MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It localizes to the CYTOSKELETON and… 
National Institutes of Health

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In BloodMAP Kinase Kinase 1MAP kinase kinase kinase activityMAP3K1 gene

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MAP3K1 protein, human

Papers overview

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2013
2013
Mutation analysis of mitogen activated protein kinase 1 gene in Indian cases of 46,XY disorder of sex development
BACKGROUND: Determination of sex is the result of cascade of molecular events that cause undifferentiated bipotential gonad to… 
2011
2011
MEK kinase 1: kinase domain deficiency in mice reveals a role in orchestrating the thymus-dependent immunity and TNFR family signaling.
  • E. Gallagher
  • Advances in experimental medicine and biology
  • 2011
  • Corpus ID: 21370651
Almost 20 years ago early work led to the cloning and identification of mitogen-activated protein kinases (MAPKs) as the apical… 
Highly Cited
2009
Highly Cited
2009
Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of post-menopausal African-American and European-American women.
FGFR2 and MAP3K1 are members of the RAS/RAF/MEK/ERK-signaling pathway and have been identified from genome-wide association… 
2005
2005
D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells
BackgroundThe family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses… 
2002
2002
Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway*
Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has been identified as a member of the mitogen… 
Highly Cited
2001
Highly Cited
2001
The NF-kappaB pathway in human endometrium and first trimester decidua.
Nuclear factor kappa B (NF-kappaB) regulates proinflammatory genes and may be involved in inflammation associated with… 
Highly Cited
1998
Highly Cited
1998
Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1*
Many growth factors and G protein-coupled receptors activate mitogen-activated protein (MAP) kinase pathways. The MAP kinase… 
Highly Cited
1998
Highly Cited
1998
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
IkappaB kinases (IKKalpha and IKKbeta) are key components of the IKK complex that mediates activation of the transcription factor… 
Highly Cited
1997
Highly Cited
1997
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain.
MEK kinase 1 (MEKK1) shares sequence identity with the yeast kinases Ste11 and Byr2, and is capable of phosphorylation and… 
Highly Cited
1996
Highly Cited
1996
Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation (*)
The Rel family of transcription factors are important mediators of various cytokine stimuli such as interleukin (IL)-1, tumor… 
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