MAP kinase kinase activity

Known as: MKK2, MKK4, ATP:protein phosphotransferase (MAPKKK-activated) activity 
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase… (More)
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
The p38 mitogen-activated protein kinase (MAPK) is activated in vitro by three different protein kinases: MKK3, MKK4, and MKK6… (More)
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Highly Cited
2000
Highly Cited
2000
The lethal factor (LF) produced by toxigenic strains of Bacillus anthracis is a Zn(2+)-endopeptidase that cleaves the mitogen… (More)
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Highly Cited
2000
Highly Cited
2000
In response to extracellular stimuli, mitogen-activated protein kinase (MAPK, also known as ERK), which localizes to the… (More)
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Highly Cited
1999
Highly Cited
1999
Interleukin-1 (IL-1) is a proinflammatory cytokine that has several effects in the inflammation process. When it binds to its… (More)
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Highly Cited
1998
Highly Cited
1998
The cellular response to treatment with proinflammatory cytokines or exposure to environmental stress is mediated, in part, by… (More)
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Highly Cited
1998
Highly Cited
1998
Activation of stress-activated protein kinases, including the p38 and the c-Jun NH2-terminal kinases (JNK), have been associated… (More)
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Highly Cited
1997
Highly Cited
1997
Several members of the tumour-necrosis/nerve-growth factor (TNF/NGF) receptor family activate the transcription factor NF-KB… (More)
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Highly Cited
1997
Highly Cited
1997
The mitogen-activated protein kinase (MAPK) cascade consisting of MAPK and its direct activator, MAPK kinase (MAPKK), is… (More)
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Highly Cited
1996
Highly Cited
1996
The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and… (More)
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Highly Cited
1993
Highly Cited
1993
The PKC1 gene of Saccharomyces cerevisiae encodes a homolog of mammalian protein kinase C that is required for normal growth and… (More)
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