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MAP kinase kinase activity

Known as: MKK2, MKK4, ATP:protein phosphotransferase (MAPKKK-activated) activity 
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

MAP Kinase Cascadeactivation of MAPK activity

Narrower (1)

MAP kinase kinase activity involved in osmosensory signaling pathway
MAP kinase kinase kinase activityMAP2K4 wt AlleleMAP3K1 geneMAPK-ERK Kinase Kinases

Papers overview

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Highly Cited
2006
Highly Cited
2006
A mitotically inheritable unit containing a MAP kinase module
Prions are novel kinds of hereditary units, relying solely on proteins, that are infectious and inherited in a non-Mendelian… 
2002
2002
Inhibition of IL‐6 signaling by a p38‐dependent pathway occurs in the absence of new protein synthesis
Negative regulation of cytokine signaling is important for limiting the intensity and duration of cytokine action and for… 
Highly Cited
2001
Highly Cited
2001
PKC δ mediates ionizing radiation-induced activation of c-Jun NH2-terminal kinase through MKK7 in human thyroid cells
The thyroid gland is one of the most sensitive organs in ionizing radiation (IR)-induced carcinogenesis. To determine, therefore… 
Highly Cited
2001
Highly Cited
2001
Pharmacologic inhibitors of MKK1 and MKK2.
Highly Cited
1999
Highly Cited
1999
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation.
c-Abl is a ubiquitously expressed protein tyrosine kinase activated by DNA damage and implicated in two responses: cell cycle… 
Highly Cited
1997
Highly Cited
1997
Altered expression of mitogen‐activated protein kinases in a rat model of experimental hepatocellular carcinoma
The mitogen‐activated protein kinase (MAPK) cascade acts as a focal point for signal transduction following activation of both G… 
Highly Cited
1995
Highly Cited
1995
Determination of v-Mos-catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS.
MAP kinase kinase (MAPKK), a key component of the MAP kinase cascade, is activated through phosphorylation by several protein… 
1994
1994
Signaling pathways mediated by the mitogen‐activated protein (MAP) kinase kinase/MAP kinase cascade
Mitogen‐activated protein (MAP) kinase and its direct activator, MAP kinase kinase (MAPKK), comprise the MAPKK/MAP kinase cascade… 
Highly Cited
1993
Highly Cited
1993
Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.
Highly Cited
1993
Highly Cited
1993
Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis
Mitogen-activated protein (MAP) kinases comprise an evolutionarily conserved family of proteins that includes at least three… 
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