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MAP Kinase Cascade

Known as: MAPK cascade, MAPKKK cascade, MAP Kinase Module 
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the… 
National Institutes of Health

Related topics

Related topics

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Narrower (8)

MAP kinase activityMAP kinase kinase activityMAP kinase kinase kinase activityMAP kinase kinase kinase kinase activity
MAPK signalingnegative regulation of MAPK cascade

Papers overview

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Highly Cited
2008
Highly Cited
2008
Arsenic trioxide decreases AKT protein in a caspase-dependent manner
Arsenic trioxide (As2O3) is used clinically to treat acute promyelocytic leukemia but is less successful in other malignancies… 
2008
2008
Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis
Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major… 
2006
2006
EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG 2 ( BCRP )
Epidermal growth factor (EGF) is a multifunctional growth factor known to play a major role in proliferation and differentiation… 
2003
2003
Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components.
The Ste5 scaffold activates an associated mitogen-activated protein kinase cascade by binding through its RING-H2 domain to a… 
Highly Cited
2002
Highly Cited
2002
Novel Protein Kinase C Isoforms Regulate Human Keratinocyte Differentiation by Activating a p38δ Mitogen-activated Protein Kinase Cascade That Targets CCAAT/Enhancer-binding Protein α*
The novel protein kinase C (nPKC) isoforms are important regulators of human involucrin (hINV) gene expression during… 
2002
2002
Insulin Signal Transduction Pathways and Insulin-induced Gene Expression*
Insulin regulates metabolic activity, gene transcription, and cell growth by modulating the activity of several intracellular… 
Highly Cited
2001
Highly Cited
2001
Dynamin and Rab5a-dependent Trafficking and Signaling of the Neurokinin 1 Receptor*
Understanding the molecular mechanisms of agonist-induced trafficking of G-protein-coupled receptors is important because of the… 
2001
2001
Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology
2001
2001
Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. I. Mitogen-activated protein kinase cascade
2000
2000
Amyloid β neurotoxicity not mediated by the mitogen-activated protein kinase cascade in cultured rat hippocampal and cortical neurons
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