The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin.
- B. Greiner, M. Eichelbaum, H. Kroemer
- Medicine, BiologyJournal of Clinical Investigation
- 15 July 1999
Concomitant administration of rifampin reduced digoxin plasma concentrations substantially after oral administration but to a lesser extent after intravenous administration, and induction of intestinal P-gp could explain this new type of drug-drug interaction.
New loci associated with kidney function and chronic kidney disease
- A. Köttgen, C. Pattaro, C. Fox
- Biology, MedicineNature Genetics
- 1 May 2010
The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry to identify new susceptibility loci for reduced renal function as estimated by serum creatinine, serum cystatin c and CKD.
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
- G. Ehret, P. Munroe, T. Johnson
- Medicine, BiologyNature
- 11 September 2011
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- I. Heid, A. Jackson, C. Lindgren
- BiologyNature Genetics
- 1 November 2010
A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Organic anion transporting polypeptide 2B1 is a high‐affinity transporter for atorvastatin and is expressed in the human heart
- M. Grube, K. Köck, H. Kroemer
- BiologyClinical pharmacology and therapy
- 1 December 2006
Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
- M. Fromm, D. Busse, H. Kroemer, M. Eichelbaum
- Medicine, BiologyHepatology
- 1 October 1996
Data indicate that prehepatic metabolism of verapamil (presumably in the gut wall) is preferentially induced compared with hepatic metabolism and that stereoselectivity of verAPamil metabolism is affected by induction.
Cohort profile: the study of health in Pomerania.
- H. Völzke, D. Alte, W. Hoffmann
- Philosophy, MedicineInternational Journal of Epidemiology
- 1 April 2011
Henry Volzke, y Dietrich Alte,1y Carsten Oliver Schmidt, Dorte Radke, Roberto Lorbeer, Nele Friedrich, Nicole Aumann, Katharina Lau, Michael Piontek, Gabriele Born, Christoph Havemann, Till…
Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects
- M. Lucht, S. Barnow, D. Rosskopf
- Psychology, BiologyProgress in Neuro-psychopharmacology and…
- 1 August 2009
The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions.
- K. Kivistö, H. Kroemer, M. Eichelbaum
- Biology, MedicineBritish Journal of Clinical Pharmacology
- 1 December 1995
Although cyclosporin and calcium channel blockers may influence the pharmacokinetics of certain anticancer agents by inhibiting their CYP3A mediated metabolism, it is more likely that these P-glycoprotein inhibitors inhibit P- glycoprotein mediated drug elimination.
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- C. Pattaro, A. Teumer, C. Fox
- Biology, MedicineNature Communications
- 21 January 2016
A meta-analysis of genome-wide association studies for estimated glomerular filtration rate suggests that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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