Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
- K. Nakahira, J. Haspel, A. Choi
- BiologyNature Immunology
- 1 March 2011
This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene*
- J. Alam, D. Stewart, C. Touchard, Sujji Boinapally, A. Choi, J. Cook
- BiologyJournal of Biological Chemistry
- 10 September 1999
Results implicate Nrf2 in the induction of the HO-1 gene but suggest that the NRF2 partner in this function is a factor other than p18 or Jun proteins.
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
- L. Otterbein, F. Bach, A. Choi
- BiologyNature Network Boston
- 30 March 2000
It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
Autophagy in human health and disease.
From the Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston (A.M.K.C., S.W.R.); and the Howard Hughes Medical…
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
- S. Brouard, L. Otterbein, M. Soares
- BiologyJournal of Experimental Medicine
- 2 October 2000
The data demonstrate that the antiapoptotic effect of HO-1 in ECs is mediated by CO and more specifically via the activation of p38 MAPK by CO.
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia*
- Patty J. Lee, B. Jiang, A. Choi
- BiologyJournal of Biological Chemistry
- 28 February 1997
Data demonstrate that hypoxia induces HO-1 expression in animal tissues and cell cultures and implicate HIF-1 in this response.
Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.
The magnitude ofHO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.
Mechanisms of cell death in oxidative stress.
- S. Ryter, Hong-pyo Kim, A. Choi
- BiologyAntioxidants and Redox Signaling
- 2007
Cell death mechanisms have been studied across a broad spectrum of models of oxidative stress, including H2O2, nitric oxide and derivatives, endotoxin-induced inflammation, photodynamic therapy, ultraviolet-A and ionizing radiations, and cigarette smoke.
Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
- Zhihua Chen, Hong-pyo Kim, A. Choi
- Biology, MedicinePLoS ONE
- 2 October 2008
A critical role for Egr-1 is demonstrated in promoting autophagy and apoptosis in response to cigarette smoke exposure in vitro and in vivo, suggesting novel therapeutic targets for the treatment of cigarette smoke induced lung injury.
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