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LY 354740

Known as: LY-354740, LY354740 
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Progress in the developement of positive allosteric modulators of the metabotropic glutamate receptor 2.
The metabotropic glutamate type 2 (mGlu2) receptor is a G-protein coupled receptor (GPCR) expressed on presynaptic nerve… 
Highly Cited
2009
Highly Cited
2009
Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture.
2009
2009
In Vitro and in Vivo Evidence for a Lack of Interaction with Dopamine D2 Receptors by the Metabotropic Glutamate 2/3 Receptor Agonists 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-bicaroxylate…
Some recently published in vitro studies with two metabotropic glutamate 2/3 receptor (mGluR2/3) agonists [(−)-2-oxa-4… 
2005
2005
Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740: Evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo
Highly Cited
2005
Highly Cited
2005
Effects of a metabotropic glutamate2/3 receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results
RationalePreclinical findings have repeatedly shown an anxiolytic-like action of agonists at metabotropic glutamate receptors… 
Highly Cited
2002
Highly Cited
2002
The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam
2001
2001
Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices
2000
2000
Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice
Antagonists of glutamate N‐methyl‐D‐aspartate (NMDA) subtype receptor inhibit the development of tolerance to the antinociceptive… 
Highly Cited
1999
Highly Cited
1999
The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal
Highly Cited
1998
Highly Cited
1998
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
To better characterize the roles of metabotropic glutamate receptors (mGluRs) in physiological and pathophysiological processes… 
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