• Publications
  • Influence
Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells*
Cannabinoids have been shown to exert anti-inflammatory activities in various in vivo and in vitro experimental models as well as ameliorate various inflammatory degenerative diseases. However, theExpand
  • 118
  • 11
Differential changes in GPR55 during microglial cell activation
We examined how lipopolysaccharide (LPS) and interferon gamma (IFN‐γ), known to differentially activate microglia, affect the expression of G protein‐coupled receptor 55 (GPR55), a novel cannabinoidExpand
  • 86
  • 9
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis‐like disease in C57BL/6 mice
BACKGROUND AND PURPOSE Cannabis extracts and several cannabinoids have been shown to exert broad anti‐inflammatory activities in experimental models of inflammatory CNS degenerative diseases.Expand
  • 102
  • 8
Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype
Cannabinoids, the Cannabis constituents, are known to possess anti-inflammatory properties but the mechanisms involved are not understood. Here we show that the main psychoactive cannabinoid,Expand
  • 56
  • 7
Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
Cannabinoids are known to exert immunosuppressive activities. However, the mechanisms which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate BV-2 microglial cells,Expand
  • 59
  • 4
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9‐tetrahydrocannabinol in BV‐2 microglial cells
BACKGROUND AND PURPOSE Apart from their effects on mood and reward, cannabinoids exert beneficial actions such as neuroprotection and attenuation of inflammation. The immunosuppressive activity ofExpand
  • 52
  • 3
Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that inhibits cell proliferation and induces cell death of cancer cells and activated immune cells. It is not an agonist of the classicalExpand
  • 61
  • 2
Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line devoid of caveolin‐1
BACKGROUND AND PURPOSE N‐acyl ethanolamines (NAEs) and 2‐arachidonoyl glycerol (2‐AG) are endogenous cannabinoids and along with related lipids are synthesized on demand from membrane phospholipids.Expand
  • 27
  • 2
Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells
BackgroundCannabidiol (CBD), the main non-psychoactive cannabinoid, has been previously shown by us to ameliorate clinical symptoms and to decrease inflammation in myelin oligodendrocyte glycoproteinExpand
  • 26
  • 2
The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells
Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that is clinically used in a 1:1 mixture with the psychoactive cannabinoid Δ9-tetrahydrocannabinol (THC) for the treatment of neuropathicExpand
  • 26
  • 2