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Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells*
Observations show that CBD and THC vary in their effects on the anti-inflammatory pathways, including the NF-κB and IFNβ-dependent pathways. Expand
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis‐like disease in C57BL/6 mice
Phytocannabinoids like cannabidiol (CBD), devoid of psychoactive activity, are, potentially, safe and effective alternatives for alleviating neuroinflammation and neurodegeneration. Expand
Differential changes in GPR55 during microglial cell activation
We examined how lipopolysaccharide (LPS) and interferon gamma (IFN‐γ), known to differentially activate microglia, affect the expression of G protein‐coupled receptor 55 (GPR55), a novel cannabinoidExpand
Nicotine and nicotinic receptor antagonists potentiate the antidepressant‐like effects of imipramine and citalopram
The present results demonstrate an unexpected interaction between nAChR ligands and imipramine and citalopram in the tail‐suspension test and the interaction betweennA ChR antagonists and antidepressants appeared synergistic. Expand
Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype
The results show a unique cannabinoid modulation of the autoimmune cytokine milieu combining suppression of the pathogenic IL-17 and IL-6 cytokines along with boosting the expression of the anti-inflammatory cytokine IL-10. Expand
Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
The findings indicate that CBD treatment leads to a biphasic increase in intracellular calcium levels and to changes in mitochondrial function and morphology leading to cell death, and the inhibition of VDAC1 by CBD may be responsible for the immunosuppressive and anticancer effects of CBD. Expand
Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice
The data suggest that both mGluR5 and NMDA receptors may be involved in the development of morphine antinociceptive tolerance, as well as the effect of co-administration of low doses of memantine and MPEP on morphine ant inociception tolerance in mice. Expand
Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
Observations indicate that CBD, and less so THC, induce a cellular stress response and that this response underlies their high immunosuppressant activities. Expand
Selective agonist of group II glutamate metabotropic receptors, LY354740, inhibits tolerance to analgesic effects of morphine in mice
The present results are the first to suggest that the development of antinociceptive morphine tolerance may be inhibited by metabotropic group II glutamate agonist. Expand
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9‐tetrahydrocannabinol in BV‐2 microglial cells
This work has shown that the psychoactive cannabinoid Δ9‐tetrahydrocannabinol (THC) and the non‐psychoactive cannabidiol (CBD) differ in their anti‐inflammatory signalling pathways. Expand