Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
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Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
- E. Tatarczyńska, A. Kłodzińska, Andrzej Pilc
- Biology, PsychologyBritish journal of pharmacology
- 1 April 2001
The data suggest that selective mGlu5 receptor antagonists may play a role in the therapy of anxiety and/or depression, further studies are required to identify the sites and the mechanism of action of MPEP.
Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men.
- J. Zoladz, Andrzej Pilc, J. Majerczak, M. Grandys, J. Zapart-Bukowska, K. Duda
- Biology, MedicineJournal of physiology and pharmacology : an…
- 1 December 2008
It is concluded that endurance training of moderate intensity increases both basal as well as the end-exercise [BDNF](p) in young healthy men.
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs.
The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies.
There may be potential benefits of the exercise-induced enhancement of the BDNF expression and release in the brain as well as in the peripheral tissues, resulting in the improvement of the functioning of the body, although this effect, especially in humans, requires more research.
The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and…
Mood disorders: regulation by metabotropic glutamate receptors.
Activation of the mGlu7 receptor elicits antidepressant-like effects in mice
- A. Pałucha, K. Kłak, P. Brański, H. Putten, P. Flor, Andrzej Pilc
- Biology, PsychologyPsychopharmacology
- 12 July 2007
Results strongly suggest that activation of the mGlu7 receptor elicits antidepressant-like effects, suggesting off-target activity of AMN082 resulting in hypo-locomotion.
Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats
Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice