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Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
TLDR
The data suggest that selective mGlu5 receptor antagonists may play a role in the therapy of anxiety and/or depression, further studies are required to identify the sites and the mechanism of action of MPEP.
Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men.
TLDR
It is concluded that endurance training of moderate intensity increases both basal as well as the end-exercise [BDNF](p) in young healthy men.
The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies.
TLDR
There may be potential benefits of the exercise-induced enhancement of the BDNF expression and release in the brain as well as in the peripheral tissues, resulting in the improvement of the functioning of the body, although this effect, especially in humans, requires more research.
Activation of the mGlu7 receptor elicits antidepressant-like effects in mice
TLDR
Results strongly suggest that activation of the mGlu7 receptor elicits antidepressant-like effects, suggesting off-target activity of AMN082 resulting in hypo-locomotion.
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment.
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