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Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
Drugs that act to reduce glutamatergic neurotransmission such as NMDA receptor antagonists exert antidepressant-like effects in a variety of experimental paradigms, but their therapeutic applicationExpand
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Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor.
DOV 216,303 [(+/-)-1-(3,4-dichlorophenyl)-3-azabicyclo-[3.1.0]hexane hydrochloride] is the prototype of a class of compounds referred to as "triple" reuptake inhibitors. Such compounds inhibit theExpand
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Lack of persistent effects of ketamine in rodent models of depression
RationaleWe investigated the immediate and enduring effects of ketamine in behavioral and neurochemical assays predictive of antidepressant activity.Materials and methodsOne week after a singleExpand
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Glutamate-based antidepressants: 20 years on.
Depression is a chronic recurring illness that affects more than 120 million people worldwide. Drugs increasing the synaptic availability of serotonin and norepinephrine (biogenic amine-based agents)Expand
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Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist
In the present study we examined the effect of MPEP [2-methyl-6-(phenylethynyl)-pyridine] a potent, selective and systemically active metabotropic glutamate receptor (mGluR) type I (subtype mGluR5)Expand
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Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor.
DOV 21,947 [(+)-1-(3,4-dichlorophenyl)-3-azabicyclo-[3.1.0]hexane hydrochloride] inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in human embryonic kidney (HEK) 293 cellsExpand
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Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.
NMDA antagonists mimic the effects of clinically effective antidepressants in both preclinical tests predictive of antidepressant action and procedures designed to model aspects of depressiveExpand
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Trait Pessimism Predicts Vulnerability to Stress-Induced Anhedonia in Rats
Depressive disorder is often associated with cognitive biases. In this study, we took a unique opportunity to investigate whether trait pessimism could predict vulnerability to stress-inducedExpand
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Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice
Phencyclidine and ketamine (but not other NMDA channel blockers, such as memantine) produce psychotomimetic effects. Since unlike memantine, phencyclidine-like compounds show no significant affinityExpand
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Serum zinc level in depressed patients during zinc supplementation of imipramine treatment.
BACKGROUND Recurrent major depression is associated with decreased blood zinc concentrations that may be increased by effective antidepressant therapy. Some clinical investigations point toExpand
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