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Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests
It is suggested that acute blockade of mGluR5 and also of mgluR1 exerts antidepressant-like effects in behavioral despair tests in rats and mice. Expand
Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor.
Preliminary evidence of a clinically meaningful antidepressant action with a molecule capable of inhibiting the three transmitters most closely linked to major depressive disorder is provided. Expand
Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist
Data suggest that mGluR5 may be involved in conditioned morphine reward and effects of MPEP on learning and memory were studied in the elevated plus maze model of spatial learning. Expand
Lack of persistent effects of ketamine in rodent models of depression
It is indicated that ketamine neither produces enduring antidepressant-like effects in rodents nor does it display antidepressant- like behavioral or neurochemical effects after chronic treatment. Expand
Glutamate-based antidepressants: 20 years on.
Evidence that glutamate-based therapies might represent an effective alternative to biogenic-amine-based agents for depression is described and perspectives on the development of these agents are provided. Expand
Trait Pessimism Predicts Vulnerability to Stress-Induced Anhedonia in Rats
For the first time, a link between cognitive judgment bias and vulnerability to stress-induced anhedonia in an animal model of depression is demonstrated and a cognitive biomarker is introduced, which may be of value for etiological depression studies. Expand
Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.
It is proposed that adaptive changes in NMDA receptors may be the final common pathway for antidepressant action. Expand
Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor.
The ability of DOV 21,947 to inhibit the reuptake of three biogenic amines closely linked to the etiology of depression may result in a therapeutic profile different from antidepressants that inhibit theReptake of serotonin and/or norepinephrine. Expand
Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice
The present data suggest that 5-HT(3) receptor blockade does not reverse the behavioral deficits of ketamine and may even enhance its certain effects, such as the antidepressant-like action. Expand
Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine.
  • P. Popik, W. Danysz
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 February 1997
It is suggested that memantine at a low, pharmacologically relevant dose of 7.5 mg/kg blocks the reinforcing effects of morphine and aversive effects of Morphine withdrawal in rats, which suggests a new potential clinical indication for this agent in the treatment of opioid abuse. Expand