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KRN 5500

Known as: 6-[4-Deoxy-4-[(2E,4E)-tetradecadienoylglycyl]amino-L-glycero-beta-L-mannohepto-pyranosyl]amino-9H-purine, KRN-5500, KRN5500 
A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces… Expand
National Institutes of Health

Related topics

Related topics

6 relations
Cell Differentiation processEndoplasmic ReticulumGolgi ApparatusPositive Regulation of Apoptosis
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Broader (1)

Purine Nucleosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
A spicamycin derivative (KRN5500) provides neuropathic pain relief in patients with advanced cancer: a placebo-controlled, proof-of-concept trial.
CONTEXT Neuropathic pain in patients with cancer can be difficult to treat effectively. OBJECTIVES The purpose of the study was… Expand
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2003
2003
KRN5500: a novel therapeutic agent with in vitro activity against human B-cell chronic lymphocytic leukemia cells mediates cytotoxicity via the intrinsic pathway of apoptosis.
Therapy of B-cell chronic lymphocytic leukemia (CLL) is currently palliative, emphasizing the need for identification of new… Expand
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2003
2003
A Single Intravenous Injection of KRN5500 (Antibiotic Spicamycin) Produces Long-Term Decreases in Multiple Sensory Hypersensitivities in Neuropathic Pain
Neuropathic pain is a significant clinical problem. Currently, there are no drugs that produce complete amelioration of this type… Expand
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2002
2002
Incorporation of the Anticancer Agent KRN5500 into Polymeric Micelles Diminishes the Pulmonary Toxicity
KRN5500 is a highly active new semi‐synthetic water‐insoluble anticancer agent. The only mechanism of anticancer activity of… Expand
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2001
2001
Population pharmacokinetic modeling and model validation of a spicamycin derivative, KRN5500, in phase 1 study
Abstract. Purpose: KRN5500, a novel spicamycin derivative, shows the greatest activity against a human tumor xenograft model and… Expand
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2000
2000
The Effects of KRN5500, a Spicamycin Derivative, on Neuropathic and Nociceptive Pain Models in Rats
We studied the effects of a spicamycin derivative, KRN5500, on two animal models of neuropathic pain (Chung and Bennett models… Expand
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Highly Cited
1999
Highly Cited
1999
Reduction of the Side Effects of an Antitumor Agent, KRN5500, by Incorporation of the Drug into Polymeric Micelles
For intravenous (i.v.) injection of a water‐insoluble antitumor drug, KRN5500, we have successfully incorporated KRN5500 into… Expand
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1997
1997
Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5500 with altered glycoprotein expression in vitro.
The spicamycin analogue KRN5500 (NSC 650426; SPA) is derived from Streptomyces alanosinicus. The unique structure contains a… Expand
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1995
1995
In vitro cytotoxicity of a novel antitumor antibiotic, spicamycin derivative, in human lung cancer cell lines.
Spicamycin (SPM), produced by Streptomyces alanosinicus, induces potent differentiation in a human leukemia cell line, HL60. One… Expand
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1994
1994
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
KRN5500, (6-[4-Deoxy-4-(2E,4E)-tetradecadienoylglycyl]amino-L-glycero - beta-L-mannoheptopyranosyl]amino-9H-purine), was semi… Expand
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