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KRN 5500

Known as: 6-[4-Deoxy-4-[(2E,4E)-tetradecadienoylglycyl]amino-L-glycero-beta-L-mannohepto-pyranosyl]amino-9H-purine, KRN-5500, KRN5500 
A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces… Expand
National Institutes of Health

Papers overview

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2012
2012
CONTEXT Neuropathic pain in patients with cancer can be difficult to treat effectively. OBJECTIVES The purpose of the study was… Expand
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2003
2003
Therapy of B-cell chronic lymphocytic leukemia (CLL) is currently palliative, emphasizing the need for identification of new… Expand
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2003
2003
Neuropathic pain is a significant clinical problem. Currently, there are no drugs that produce complete amelioration of this type… Expand
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2002
2002
KRN5500 is a highly active new semi‐synthetic water‐insoluble anticancer agent. The only mechanism of anticancer activity of… Expand
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2001
2001
Abstract. Purpose: KRN5500, a novel spicamycin derivative, shows the greatest activity against a human tumor xenograft model and… Expand
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2000
2000
We studied the effects of a spicamycin derivative, KRN5500, on two animal models of neuropathic pain (Chung and Bennett models… Expand
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Highly Cited
1999
Highly Cited
1999
For intravenous (i.v.) injection of a water‐insoluble antitumor drug, KRN5500, we have successfully incorporated KRN5500 into… Expand
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1997
1997
The spicamycin analogue KRN5500 (NSC 650426; SPA) is derived from Streptomyces alanosinicus. The unique structure contains a… Expand
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1995
1995
Spicamycin (SPM), produced by Streptomyces alanosinicus, induces potent differentiation in a human leukemia cell line, HL60. One… Expand
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1994
1994
KRN5500, (6-[4-Deoxy-4-(2E,4E)-tetradecadienoylglycyl]amino-L-glycero - beta-L-mannoheptopyranosyl]amino-9H-purine), was semi… Expand
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