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A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice. Expand
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor. Expand
Toxic effects of ultraviolet radiation on the skin.
In the clinic, artificial lamps emitting UVB and UVA radiation in combination with chemical drugs are used in the therapy of many skin diseases including psoriasis and vitiligo, and although such therapy is beneficial, it is accompanied with undesirable side effects. Expand
Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
The maximum-tolerated dose (MTD) and dose-limiting toxicities (DLTs) of NK911 were defined and a partial response was obtained in one patient with metastatic pancreatic cancer and its pharmacokinetic profile in man was well tolerated. Expand
Phase I/II study of S-1 combined with cisplatin in patients with advanced gastric cancer
This regimen is considered to be active against AGC with acceptable toxicity, and the maximum-tolerated dose, recommended dose, dose-limiting toxicities (DLTs), and objective response rate (RR) in advanced gastric cancer (AGC). Expand
Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors, according to the passive targeting manner, and its utility as a tumor-targeted drug delivery system was investigated. Expand
MicroRNA Expression Profiling of Exfoliated Colonocytes Isolated from Feces for Colorectal Cancer Screening
To reduce the colorectal cancer (CRC) mortality rate, we have reported several CRC screening methods using colonocytes isolated from feces. Expression analysis of oncogenic microRNA (miRNA) inExpand
Tumoritropic and lymphotropic principles of macromolecular drugs.
Improvements in protein drugs, after tailoring with polymers, are as follows: increased plasma half-life, loss of antigenecity, lymphotropism, and, especially, preferred tumor-targeting efficiency and long-term retention in the tumor tissues. Expand
A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation
The maximum tolerated dose (MTD), the dose-limiting toxicities (DLTs), the recommended dose (RD) for phase II, and the pharmacokinetics of NK105, a new polymeric micelle carrier system for paclitaxel (PTX) were examined. Expand
Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors
NK012 was well tolerated and showed antitumor activity including partial responses and several occurrences of prolonged stable disease across a variety of advanced refractory cancers. Expand