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Innovative Approach for Improvement of an Antibiotic-Overproducing Industrial Strain of Streptomyces albus
TLDR
It is concluded that this aberrant protein synthesis ability in the Strr mutant, which is a result of increased stability of the 70S complex, is responsible for the remarkable salinomycin production enhancement obtained.
A LINEAR PLASMID-LIKE DNA IN STREPTOMYCES SP. PRODUCING LANKACIDIN GROUP ANTIBIOTICS
TLDR
Results suggest that the linear plasmid-like DNA was isolated from a lysate of Streptomyces sp.
Salinomycin Effects on Mitochondrial Ion Translocation and Respiration
TLDR
It is proposed that salinomycin perturbs mitochondrial functions by acting as a mobile carrier for alkali cations through membranes in rat liver mitochondria by inhibition of adenosine triphosphatase activity and Oxidative phosphorylation.
Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
TLDR
SPM VIII showed the most activity against SC-9 in the human tumor xenograft model with the highest therapeutic index among SPMs, and the antitumor activity of SPM VIII was superior to that of mitomycin C.
Isolation and synthesis of a new bioactive ellagic acid derivative from Combretum yunnanensis.
TLDR
Compound 1 showed weak inhibitory activity against the growth of various tumor cells and inhibited HIV-1 protease and the absolute configuration of 1 was determined.
Capuramycin, a new nucleoside antibiotic. Taxonomy, fermentation, isolation and characterization.
TLDR
The taxonomy of a producing organism, fermentation, isolation, characterization, characterization and biological properties of capuramycin are described.
New morpholino anthracyclines, MX, MX2, and MY5.
Studies on the biosynthesis of bialaphos (SF-1293). 2. Isolation of the first natural products with a C-P-H bond and their involvement in the C-P-C bond formation.
TLDR
2-Phosphinomethylmalic acid synthase catalyzes the condensation of phosphinopyruvic acid, an analog of oxalacetic acid, and acetyl-CoA to form PMM, which is very similar to (R)-citrate synthase of Clostridium in the inhibition pattern by sulfhydryl compounds, its metal ion requirement and stereospecificity.
Neorustmicin A, a new macrolide antibiotic active against wheat stem rust fungus.
TLDR
During the course of further screening, a new antibiotic neorustmicin A (I) was found in the cultured broth of Micromonospora chalcea 1302AV2, a pathogen known as stem rust caused by the infection of Puccinia graminis f.
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