• Publications
  • Influence
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
KRN5500 prolonged the survival of P388 leukemia- and B16 melanoma-bearing mice but was marginally effective on colon adenocarcinoma 26 and was ineffective even at 170 microM in inhibition of protein synthesis in rabbit reticulocyte lysates.
Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
SPM VIII showed the most activity against SC-9 in the human tumor xenograft model with the highest therapeutic index among SPMs, and the antitumor activity of SPM VIII was superior to that of mitomycin C.
Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp.
Formobactin inhibited lipid peroxidation in rat brain homogenate and showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.
Results indicate that ICE or ICE-like proteases inhibited by Z-Asp-CH2-DCB are involved in a common pathway of apoptotic cell death in U937 cells.
New morpholino anthracyclines, MX, MX2, and MY5.
Biocidal Polystyrenehydantoin Beads. 2. Control of Chlorine Loading
It has been demonstrated that the biocidal polymers poly-1,3-dichloro-5-methyl-5-(4‘-vinylphenyl)hydantoin and the alkali metal salt and protonated forms of its monochlorinated derivative can be
Studies on free radical scavenging substances from microorganisms. III. Isolation and structural elucidation of a novel free radical scavenger, resorstatin.
The isolation, structural elucidation and biological activity of resorstatin are reported and it is shown that this compound has shown a strong inhibitory activity against lipid peroxidation induced by free radicals in rat brain homogenate.