H. Kawai

Publications62
h-index18
Citations1,083
Highly Influential Citations17
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Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
TLDR
KRN5500 prolonged the survival of P388 leukemia- and B16 melanoma-bearing mice but was marginally effective on colon adenocarcinoma 26 and was ineffective even at 170 microM in inhibition of protein synthesis in rabbit reticulocyte lysates.
Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
TLDR
SPM VIII showed the most activity against SC-9 in the human tumor xenograft model with the highest therapeutic index among SPMs, and the antitumor activity of SPM VIII was superior to that of mitomycin C.
Formobactin, a novel free radical scavenging and neuronal cell protecting substance from Nocardia sp.
TLDR
Formobactin inhibited lipid peroxidation in rat brain homogenate and showed the activity to suppress L-glutamate toxicity in neuronal hybridoma N18-RE-105 cells.
Kalihinene and isokalihinol B, cytotoxic diterpene isonitriles from the marine sponge Acanthella klethra
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.
TLDR
Results indicate that ICE or ICE-like proteases inhibited by Z-Asp-CH2-DCB are involved in a common pathway of apoptotic cell death in U937 cells.
New morpholino anthracyclines, MX, MX2, and MY5.
Collismycins A and B, novel non-steroidal inhibitors of dexamethasone-glucocorticoid receptor binding.
Biocidal Polystyrenehydantoin Beads. 2. Control of Chlorine Loading
It has been demonstrated that the biocidal polymers poly-1,3-dichloro-5-methyl-5-(4‘-vinylphenyl)hydantoin and the alkali metal salt and protonated forms of its monochlorinated derivative can be…
Studies on free radical scavenging substances from microorganisms. III. Isolation and structural elucidation of a novel free radical scavenger, resorstatin.
TLDR
The isolation, structural elucidation and biological activity of resorstatin are reported and it is shown that this compound has shown a strong inhibitory activity against lipid peroxidation induced by free radicals in rat brain homogenate.
Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.
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