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KRN7000, a novel immunomodulator, and its antitumor activities.
It is demonstrated that KRN7000 would be a useful agent for cancer therapy because its potency on in vivo NK activity was much stronger than that of Mitomycin C, a typical chemotherapeutic agent, in two models.
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
KRN5500 prolonged the survival of P388 leukemia- and B16 melanoma-bearing mice but was marginally effective on colon adenocarcinoma 26 and was ineffective even at 170 microM in inhibition of protein synthesis in rabbit reticulocyte lysates.
Structure-antitumor activity relationship of semi-synthetic spicamycin analogues.
- M. Kamishohara, H. Kawai, +7 authors N. Ōtake
- Biology, MedicineThe Journal of antibiotics
- 25 September 1993
SPM VIII showed the most activity against SC-9 in the human tumor xenograft model with the highest therapeutic index among SPMs, and the antitumor activity of SPM VIII was superior to that of mitomycin C.
Saquayamycins, new aquayamycin-group antibiotics.
From the culture broth of Streptomyces nodosus MH190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1).
Antitumor activities of α-, β-monogalactosylceramides and four diastereomers of an α-galactosylceramide
We examined antitumor activities of α-, β-monoglycosylceramides (MonoCers) and four diastereomers of an α-galactosylceramide (α-GalCer), and found that the α-GalCer among MonoCers and the 2S, 3R type…
New potent anthracyclines, barminomycins I and II.
Dioxamycin, a new benz[a]anthraquinone antibiotic.
- R. Sawa, N. Matsuda, +5 authors T. Takeuchi
- Chemistry, MedicineThe Journal of antibiotics
- 25 April 1991
A new antibiotic, dioxamycin was isolated from the culture broth of the strain MH406-SF1, which was closely related to Streptomyces xantholiticus, which is active in vitro against Gram-positive bacteria and some tumor cells.
Enhancing effects of alpha-,beta-monoglycosylceramides on natural killer cell activity.
- E. Kobayashi, K. Motoki, Y. Yamaguchi, T. Uchida, H. Fukushima, Y. Koezuka
- MedicineBioorganic & medicinal chemistry
It is suggested that the manner of combination between sugar and ceramide plays an important role in antitumor activity as well as enhancing effect on NK cell activity of GalCers.
Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.
New antitumor antibiotics, ditrisarubicins A, B and C.