• Publications
  • Influence
Modulation of Akt kinase activity by binding to Hsp90.
TLDR
Results indicate that Hsp90 plays an important role in maintaining Akt kinase activity by preventing PP2A-mediated dephosphorylation. Expand
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
TLDR
The results suggest that the protein has a role in the normal secretion of metabolites and certain anti-cancer drugs into bile, urine, and directly into the lumen of the gastrointestinal tract. Expand
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors.
TLDR
Results suggest that MS-27-275 acts as an antitumor agent through HDA inhibition and may provide a novel chemotherapeutic strategy for cancers insensitive to traditional antitumors. Expand
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.
TLDR
VCR resistance was almost completely overcome in vivo and in vitro and could be explained by the effective accumulation of VCR by verapamil in P388/VCR cells mediated by the inhibition of a VCR efflux function of the cells, a mechanism which remains to be solved. Expand
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.
TLDR
People with C376T and/or C421A polymorphisms may express low amounts of BCRP, and this low BCRp expression might result in hypersensitivity of normal cells to such anticancer drugs as irinotecan and mitoxantrone. Expand
Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization*
TLDR
Akt promotes cell-cycle progression through the mechanisms of phosphorylation-dependent 14-3-3 binding to p27Kip1 and cytoplasmic localization and the COOH-terminal Thr198 residue as a novel site. Expand
Involvement of 14‐3‐3 proteins in nuclear localization of telomerase
TLDR
It is suggested that 14‐3‐3 enhances nuclear localization of TERT by inhibiting the CRM1 binding to the TERT NES‐like motif. Expand
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
TLDR
It is demonstrated that Rap1 plays a pivotal role in chemokine-induced integrin activation and migration and induced a polarized morphology, accompanied by the redistribution of CXCR4 and CD44 to the leading edge and uropod, respectively. Expand
Domain Mapping Studies Reveal That the M Domain of hsp90 Serves as a Molecular Scaffold to Regulate Akt-Dependent Phosphorylation of Endothelial Nitric Oxide Synthase and NO Release
TLDR
It is demonstrated that stimulation of endothelial cells with vascular endothelial growth factor recruits eNOS and Akt to an adjacent region on the same domain of hsp90, thereby facilitating eN OS phosphorylation and enzyme activation. Expand
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
TLDR
The results suggest that the constitutive activation of 41-/43-kDa MAP kinases in tumor cells is not due to the disorder of MAP kinase themselves, but is due toThe disorder of Raf-1, Ras, or some other signaling molecules upstream of Ras. Expand
...
1
2
3
4
5
...