KCNJ6 gene

Known as: KATP2, potassium voltage-gated channel subfamily J member 6, POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 7, FORMERLY

National Institutes of Health

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2019

The relationship between single nucleotide polymorphisms in ARRB2, KCNJ6 and BDNF genes and methadone response for pain management in palliative care.

Deniz Ozberk
2019
Corpus ID: 212810355

Background: Pain has a negative impact on cancer patients’ quality of life. It is highly prevalent within this vulnerable…

2015

Regulation of SOBIR1 accumulation and defence activation in an autoimmune mutant by specific components of ER quality control.

Z. Qian
2015
Corpus ID: 87694240

........................................................................................................................................................... ii Preface ............................................................................................................................................................ iii Table of contents .......................................................................................................................................... v List of figures .............................................................................................................................................. vii List of abbreviations ................................................................................................................................ viii Acknowledgements .................................................................................................................................... xi Chapter 1: Introduction ............................................................................................................................. 1 1.1 Plant immunity ............................................................................................................... 1 1.2 Receptor-like kinases (RLKs) and receptor-like proteins (RLPs) ................ 3 1.3 Genetic analysis of defence responses regulated by BIR1 and SOBIR1 ... 4 1.4 ER-QC in plant immunity .......................................................................................... 7 Chapter 2: Regulation of SOBIR1 accumulation and activation of defence responses in bir1-1 by ER-quality control components CRT3, ERdj3b and SDF2 ..................................... 12 2.1 Introduction ...................................................................................................................... 12 2.2 Results ................................................................................................................................ 15 2.2.1 Identification and characterization of sobir3-1 bir1-1 pad4-1 ........... 15 2.2.2 SOBIR3 encodes CALRETICULIN 3 ........................................................ 17 2.2.3 CRT3 is required for cell death and defence responses in bir1-1 ..... 19 2.2.4 Identification of an allele of erdj3b that supresses bir1-1 pad4-1 mutant phenotypes ....................................................................................................... 21 2.2.5 ERdj3b is required for cell death and defence responses in bir1-1 .. 23 2.2.6 Identification of an allele of sdf2 that supresses bir1-1 pad4-1 mutant phenotypes ...................................................................................................................... 25 2.2.7 SDF2 is required for cell death and defence responses in bir1-1 ...... 27 2.2.8 CRT3 and ERdj3b are required for the accumulation of SOBIR1 ... 29 2.3 Discussion ......................................................................................................................... 30 2.4 Experimental procedures .............................................................................................. 32 2.4.1 Plant material ...................................................................................................... 32 2.4.2 Mutant characterization ................................................................................... 33 vi 2.4.3 Analysis of SOBIR1 protein levels in crt3-1 and erdj3b-1 mutant plants ................................................................................................................................ 34 Chapter 3: Regulation of SOBIR1 accumulation and activation of defence responses in bir1-1 by ER-quality control components UGGT and STT3a ................................................... 35 3.1 Introduction ...................................................................................................................... 35 3.2 Results ................................................................................................................................ 37 3.2.1 Identification and characterization of sobir6-1 bir1-1 pad4-1 ........... 37 3.2.2 SOBIR6 encodes UGGT ................................................................................. 38 3.2.3 UGGT is required for constitutive defence responses in bir1-1 ........ 41 3.2.4 The autoimmune phenotype of bir1-1 is partially suppressed by stt3a-2 .............................................................................................................................. 42 3.2.5 Accumulation of SOBIR1 is reduced in sobir6-1 but unaffected in stt3a-2 .............................................................................................................................. 45 3.3 Discussion ......................................................................................................................... 46 3.4 Experimental procedures .............................................................................................. 48 3.4.1 Plant material ...................................................................................................... 48 3.4.2 Mutant characterization ................................................................................... 48 3.4.3 Analysis of SOBIR1 protein levels in sobir6-1 and stt3a-2 mutant plants ................................................................................................................................ 49 Chapter 4: Future directions and conclusions .................................................................................. 50 References: .................................................................................................................................................. 52