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Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
Cloned Drosophila homologs of rac and CDC42, Drac1, and Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis. Expand
Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit
Using Axolotl oocytes as an expression system, TMEM16A is identified as the Xenopus oocyte CaCC and may help the development of CaCC modulators for treating diseases including hypertension and cystic fibrosis. Expand
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
Direct evidence is presented that NMDA receptors exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and NR2B subunits. Expand
Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
It is reported that selection of the future axon among neurites of a cultured hippocampal neuron requires the activity of growth factor receptor tyrosine kinase, phosphatidylinositol 3-kinase, as well as atypical protein kinase C (aPKC). Expand
Properties of the larval neuromuscular junction in Drosophila melanogaster.
The anatomy and physiology of the Drosophila larval neuromuscular junction were studied and Mg2+ reduces transmitter release without altering the fourth power dependence on [Ca2+]o. Expand
Tiling of the Drosophila epidermis by multidendritic sensory neurons.
Together, the data suggest that widespread tiling of the larval body wall involves interactions between growing dendritic processes and as yet unidentified signals that allow avoidance by like dendrites. Expand
Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch
It is shown that Notch, a transmembrane receptor mediated cell-cell communication, functions as a binary switch in cell fate specification during asymmetric divisions of the SOP and its daughter cells in embryogenesis. Expand
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
It is determined by immunocytochemistry that numb is a membrane-associated protein which localizes asymmetrically to one-half of the predivisional SOP cell, and functions to determine the fates of the secondary precursors. Expand
Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway
In both Drosophila and rodent neurons, defects in Sar1 expression preferentially affected dendritic growth, revealing evolutionarily conserved difference in the sensitivity to limiting membrane supply from the secretory pathway. Expand
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
It is reported that stardust encodes single PDZ domain MAGUK (membrane-associated guanylate kinase) proteins that are expressed in all primary embryonic epithelia from the onset of gastrulation. Expand