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- Publications
- Influence
TREK‐1 is a heat‐activated background K+ channel
- F. Maingret, I. Lauritzen, +5 authors E. Honoré
- Biology, Medicine
- The EMBO journal
- 1 June 2000
Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres as… Expand
The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans(*)
- R. Waldmann, G. Champigny, N. Voilley, I. Lauritzen, M. Lazdunski
- Biology, Medicine
- The Journal of Biological Chemistry
- 3 May 1996
Mutations of the degenerins (deg-1, mec-4, mec-10) are the major known causes of hereditary neurodegeneration in the nematode Caenorhabditis elegans. We cloned a neuronal degenerin (MDEG) from human… Expand
Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning.
- C. Heurteaux, I. Lauritzen, C. Widmann, M. Lazdunski
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 9 May 1995
Preconditioning with sublethal ischemia protects against neuronal damage after subsequent lethal ischemic insults in hippocampal neurons. A pharmacological approach using agonists and antagonists at… Expand
A phospholipid sensor controls mechanogating of the K+ channel TREK‐1
- J. Chemin, A. Patel, F. Duprat, I. Lauritzen, M. Lazdunski, E. Honoré
- Biology, Medicine
- The EMBO journal
- 12 January 2005
TREK‐1 (KCNK2 or K2P2.1) is a mechanosensitive K2P channel that is opened by membrane stretch as well as cell swelling. Here, we demonstrate that membrane phospholipids, including PIP2, control… Expand
Polyunsaturated fatty acids are potent neuroprotectors
- I. Lauritzen, N. Blondeau, C. Heurteaux, C. Widmann, G. Romey, M. Lazdunski
- Biology, Medicine
- The EMBO journal
- 17 April 2000
Results reported in this work suggest a potential therapeutic value of polyunsaturated fatty acids for cerebral pathologies as previously proposed by others for cardiac diseases. We show that the… Expand
A TREK-1-Like Potassium Channel in Atrial Cells Inhibited by &bgr;-Adrenergic Stimulation and Activated by Volatile Anesthetics
- C. Terrenoire, I. Lauritzen, F. Lesage, G. Romey, M. Lazdunski
- Chemistry, Medicine
- Circulation research
- 17 August 2001
Many members of the two-pore-domain potassium (K+) channel family have been detected in the mammalian heart but the endogenous correlates of these channels still have to be identified. We… Expand
The TASK background K2P channels: chemo- and nutrient sensors
- F. Duprat, I. Lauritzen, A. Patel, E. Honoré
- Chemistry, Medicine
- Trends in Neurosciences
- 1 November 2007
Specialized chemo- and nutrient-sensing cells share a common electrophysiological mechanism by transducing low O(2), high CO(2) and low glucose stimuli into a compensatory cellular response: the… Expand
The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3
- N. Tinel, I. Lauritzen, C. Chouabe, M. Lazdunski, M. Borsotto
- Biology, Medicine
- FEBS letters
- 6 November 1998
Benign familial neonatal convulsions, an autosomal dominant epilepsy of newborns, are linked to mutations affecting two six‐transmembrane potassium channels, KCNQ2 and KCNQ3. We isolated four splice… Expand
Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease
- B. Oulès, D. Del Prete, +9 authors M. Chami
- Biology, Medicine
- The Journal of Neuroscience
- 22 August 2012
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the… Expand
M‐type KCNQ2–KCNQ3 potassium channels are modulated by the KCNE2 subunit
- N. Tinel, S. Diochot, I. Lauritzen, J. Barhanin, M. Lazdunski, M. Borsotto
- Biology, Medicine
- FEBS letters
- 1 September 2000
KCNQ2 and KCNQ3 subunits belong to the six transmembrane domain K+ channel family and loss of function mutations are associated with benign familial neonatal convulsions. KCNE2 (MirP1) is a single… Expand