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Islet Amyloid Polypeptide, human

Known as: Insulinoma Amyloid Peptide, Amylin, Diabetes-Associated Peptide 
Islet amyloid polypeptide (89 aa, ~10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
AmylinApoptosisExtracellular SpaceIAPP gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
A single-point mutation converts the highly amyloidogenic human islet amyloid polypeptide into a potent fibrillization inhibitor.
Aggregation and amyloid formation play critical roles in a range of human diseases including type 2 diabetes. Islet amyloid… 
Highly Cited
2003
Highly Cited
2003
Size-tunable emission from 1,3-diphenyl-5-(2-anthryl)-2-pyrazoline nanoparticles.
Organic nanoparticles of 1,3-diphenyl-5-(2-anthryl)-2- pyrazoline (DAP) ranging in average diameters from 40 to 160 nm were… 
Highly Cited
2003
Highly Cited
2003
Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation.
Highly Cited
2001
Highly Cited
2001
Analysis of the Minimal Amyloid-forming Fragment of the Islet Amyloid Polypeptide
The development of type II diabetes was shown to be associated with the formation of amyloid fibrils consisted of the islet… 
Highly Cited
2000
Highly Cited
2000
Alzheimer's β-Amyloid, Human Islet Amylin, and Prion Protein Fragment Evoke Intracellular Free Calcium Elevations by a Common Mechanism in a Hypothalamic GnRH Neuronal Cell Line*
A growing number of reports suggest that elevated levels of extracellular Alzheimer's β-amyloid protein alter the homeostasis of… 
Review
1999
Review
1999
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn of the century. It has as its unique… 
Highly Cited
1999
Highly Cited
1999
Watching amyloid fibrils grow by time-lapse atomic force microscopy.
Late-onset diabetes is typically associated with amyloid deposits of fibrillar amylin in the pancreatic islets. Aqueous synthetic… 
Highly Cited
1998
Highly Cited
1998
ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis
ABSTRACT We have identified a novel serine/threonine kinase, designated ZIP kinase, which mediates apoptosis. ZIP kinase contains… 
Highly Cited
1997
Highly Cited
1997
DAP‐kinase is a Ca2+/calmodulin‐dependent, cytoskeletal‐associated protein kinase, with cell death‐inducing functions that depend on its catalytic activity
DAP‐kinase was initially identified as a gene whose anti‐sense‐mediated reduced expression protected HeLa cells from interferon… 
Highly Cited
1997
Highly Cited
1997
Polymorphic fibrillar assembly of human amylin.
Human amylin forms fibrillar amyloid between pancreatic islet cells in patients with non-insulin-dependent (type 2) diabetes… 
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