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Amylin

Known as: Islet Amyloid Polypeptide, Polypeptide, Islet Amyloid, Insulinoma Amyloid Polypeptide 
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid… Expand
National Institutes of Health

Related topics

Related topics

20 relations

Broader (3)

Amylin Receptor AgonistsAppetite DepressantsPancreatic Polypeptide
Amyloid ProteinsDAP geneDiabetes Mellitus, Non-Insulin-DependentIAPP gene
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Narrower (2)

Islet Amyloid Polypeptide PrecursorPramlintide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Long-term persistence of hormonal adaptations to weight loss.
BACKGROUND After weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic… Expand
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Highly Cited
2010
Highly Cited
2010
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid… Expand
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Highly Cited
2008
Highly Cited
2008
Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin).
Human islet amyloid polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of… Expand
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Highly Cited
2007
Highly Cited
2007
Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.
The 37-residue amylin peptide, also known as islet amyloid polypeptide, forms fibrils that are the main peptide or protein… Expand
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Highly Cited
2003
Highly Cited
2003
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass… Expand
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Highly Cited
1998
Highly Cited
1998
Differential Permeability of the Blood–Brain Barrier to Two Pancreatic Peptides: Insulin and Amylin
Insulin and amylin are cosecreted by pancreatic B cells and have receptors within the central nervous system (CNS), where they… Expand
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Review
1997
Review
1997
Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.
The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. CT and… Expand
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Highly Cited
1996
Highly Cited
1996
Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin (*)
Amylin is a 37-amino acid cytotoxic constituent of amyloid deposits found in the islets of Langerhans of patients with type II… Expand
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Highly Cited
1994
Highly Cited
1994
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
THE 37-amino-acid polypeptide amylin is the principal constituent of the amyloid deposits that form in the islets of Langerhans… Expand
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Highly Cited
1990
Highly Cited
1990
Effects of Meal Ingestion on Plasma Amylin Concentration in NIDDM and Nondiabetic Humans
Recent interest has focused on the potential role of amylin in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM… Expand
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