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Amylin

Known as: Islet Amyloid Polypeptide, Polypeptide, Islet Amyloid, Insulinoma Amyloid Polypeptide 
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid… 
National Institutes of Health

Related topics

Related topics

20 relations

Broader (3)

Amylin Receptor AgonistsAppetite DepressantsPancreatic Polypeptide
Amyloid ProteinsDAP geneDiabetes Mellitus, Non-Insulin-DependentIAPP gene

Narrower (2)

Islet Amyloid Polypeptide PrecursorPramlintide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid… 
Review
2009
Review
2009
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European…
We appreciate Dr. Woo's response to our study (1) and his comparison (2) of the Canadian Diabetes Association (CDA) clinical… 
Highly Cited
2007
Highly Cited
2007
Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.
The 37-residue amylin peptide, also known as islet amyloid polypeptide, forms fibrils that are the main peptide or protein… 
Highly Cited
2003
Highly Cited
2003
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass… 
Review
2002
Review
2002
International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related peptides (CGRPs), and adrenomedullin… 
Review
1997
Review
1997
Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.
The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. CT and… 
Highly Cited
1996
Highly Cited
1996
Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin (*)
Amylin is a 37-amino acid cytotoxic constituent of amyloid deposits found in the islets of Langerhans of patients with type II… 
Highly Cited
1994
Highly Cited
1994
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
THE 37-amino-acid polypeptide amylin is the principal constituent of the amyloid deposits that form in the islets of Langerhans… 
Highly Cited
1990
Highly Cited
1990
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.
Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic beta-cells and the major constituent… 
Highly Cited
1987
Highly Cited
1987
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.
Amyloid deposits localized to the islets of Langerhans are typical of non-insulin-dependent human diabetes mellitus and of… 
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