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Amylin
Known as:
Islet Amyloid Polypeptide
, Polypeptide, Islet Amyloid
, Insulinoma Amyloid Polypeptide
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A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid…
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National Institutes of Health
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Related topics
Related topics
20 relations
Broader (3)
Amylin Receptor Agonists
Appetite Depressants
Pancreatic Polypeptide
Amyloid Proteins
DAP gene
Diabetes Mellitus, Non-Insulin-Dependent
IAPP gene
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Narrower (2)
Islet Amyloid Polypeptide Precursor
Pramlintide
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
S. Masters
,
A. Dunne
,
+19 authors
L. O’Neill
Nature Immunology
2010
Corpus ID: 2009456
Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid…
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Review
2009
Review
2009
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European…
D. Nathan
Diabetes Care
2009
Corpus ID: 1448110
We appreciate Dr. Woo's response to our study (1) and his comparison (2) of the Canadian Diabetes Association (CDA) clinical…
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Highly Cited
2007
Highly Cited
2007
Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.
S. Luca
,
W. Yau
,
R. Leapman
,
R. Tycko
Biochemistry
2007
Corpus ID: 8121667
The 37-residue amylin peptide, also known as islet amyloid polypeptide, forms fibrils that are the main peptide or protein…
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Highly Cited
2003
Highly Cited
2003
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
A. Butler
,
J. Janson
,
S. Bonner-Weir
,
R. Ritzel
,
R. Rizza
,
P. Butler
Diabetes
2003
Corpus ID: 16660076
Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass…
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Review
2002
Review
2002
International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors
D. Poyner
,
P. Sexton
,
+6 authors
S. Foord
Pharmacological Reviews
2002
Corpus ID: 17302944
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related peptides (CGRPs), and adrenomedullin…
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Review
1997
Review
1997
Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily.
S. Wimalawansa
Critical reviews in neurobiology
1997
Corpus ID: 29938870
The calcitonin gene peptide superfamily consists of calcitonin (CT), calcitonin gene-related peptide (CGRP), and amylin. CT and…
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Highly Cited
1996
Highly Cited
1996
Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin (*)
T. Mirzabekov
,
Meng-chin A. Lin
,
B. Kagan
The Journal of Biological Chemistry
1996
Corpus ID: 10774700
Amylin is a 37-amino acid cytotoxic constituent of amyloid deposits found in the islets of Langerhans of patients with type II…
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Highly Cited
1994
Highly Cited
1994
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
A. Lorenzo
,
B. Razzaboni
,
G. Weir
,
B. Yankner
Nature
1994
Corpus ID: 4244347
THE 37-amino-acid polypeptide amylin is the principal constituent of the amyloid deposits that form in the islets of Langerhans…
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Highly Cited
1990
Highly Cited
1990
Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.
P. Westermark
,
U. Engström
,
K. Johnson
,
G. Westermark
,
C. Betsholtz
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 24620108
Islet amyloid polypeptide (IAPP), a putative polypeptide hormone, is a product of pancreatic beta-cells and the major constituent…
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Highly Cited
1987
Highly Cited
1987
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.
P. Westermark
,
C. Wernstedt
,
E. Wilander
,
D. W. Hayden
,
T. O’Brien
,
K. Johnson
Proceedings of the National Academy of Sciences…
1987
Corpus ID: 25130885
Amyloid deposits localized to the islets of Langerhans are typical of non-insulin-dependent human diabetes mellitus and of…
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