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Mechanisms linking obesity to insulin resistance and type 2 diabetes
In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance.
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.
- S. Kahn, S. Haffner, +8 authors G. Viberti
- MedicineThe New England journal of medicine
- 7 December 2006
The potential risks and benefits, the profile of adverse events, and the costs of these three drugs should all be considered to help inform the choice of pharmacotherapy for patients with type 2 diabetes.
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
- S. Kahn
- Biology, MedicineDiabetologia
- 11 January 2003
Greater understanding of the relative roles of insulin resistance and beta-cell dysfunction in Type 2 diabetes can anticipate advances in the identification of genes contributing to the development of the disease as well as approaches to the treatment and prevention of Type 1 diabetes.
Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function
In human subjects with normal glucose tolerance and varying degrees of obesity, β-cell function varies quantitatively with differences in insulin sensitivity, consistent with a regulated feedback loop control system.
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
It is shown that oligomers of islet amyloid polypeptide (IAPP), a protein that formsAmyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β.
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
More effective therapies to slow progressive loss of β-cell function are needed and additional long-term studies of drugs and bariatric surgery are needed to identify new ways to prevent and treat type 2 diabetes and thereby reduce the harmful effects of this disease.
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
It is suggested that adiponectin concentrations are determined by intra-abdominal fat mass, with additional independent effects of age and sex, and could link intra- abdominalFat with insulin resistance and an atherogenic lipoprotein profile.
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
At 1 year, ILI resulted in clinically significant weight loss in people with type 2 diabetes and was associated with improved diabetes control and CVD risk factors and reduced medicine use in ILI versus DSE.
Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.
- R. Ratner, C. Christophi, +5 authors S. Kahn
- MedicineThe Journal of clinical endocrinology and…
- 1 December 2008
Progression to diabetes is more common in women with a history of GDM compared with those without GDM history despite equivalent degrees of IGT at baseline, and both intensive lifestyle and metformin are highly effective in delaying or preventing diabetes in Women with IGT and a historyof GDM.
Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity*
- U. Pajvani, M. Hawkins, +12 authors P. Scherer
- Biology, MedicineJournal of Biological Chemistry
- 26 March 2004
It is demonstrated that changes in SA in a number of type 2 diabetic cohorts serve as a quantitative indicator of improvements in insulin sensitivity obtained during TZD treatment, whereas changes in total serum adiponectin levels do not correlate well at the individual level.