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Interleukin 4 Receptor

Known as: Receptor, IL4, IL-4 Receptors, Receptors, IL 4 
Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4. They are involved in… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (2)

CD AntigensInterleukin Receptor
IL4R geneIL4R wt AlleleIn Bloodagonists

Narrower (2)

IL4R protein, humanInterleukin-4 Receptor alpha Subunit

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
An essential role for the Th2-type response in limiting tissue damage during helminth infection
Helminths induce potent T helper 2 (TH2)-type immune responses that can mediate worm expulsion, but the role of this response in… 
Highly Cited
2008
Highly Cited
2008
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
The interleukin 4 receptor (IL-4R) is a central mediator of T helper type 2 (TH2)–mediated disease and associates with either the… 
Highly Cited
2006
Highly Cited
2006
IL-4 Receptor α Is an Important Modulator of IL-4 and IL-13 Receptor Binding: Implications for the Development of Therapeutic Targets1
IL-4 is a key cytokine associated with allergy and asthma. Induction of cell signaling by IL-4 involves interaction with its… 
Highly Cited
2002
Highly Cited
2002
Differential Functions of IL-4 Receptor Types I and II for Dendritic Cell Maturation and IL-12 Production and Their Dependency on GM-CSF1
Little is known about the distinct roles of the two types of IL-4R on DC. Here we report that IL-4 and IL-13 are able to promote… 
Highly Cited
2001
Highly Cited
2001
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma.
BACKGROUND IL-4 mediates important proinflammatory functions in asthma, including induction of the IgE isotype switch, increased… 
Highly Cited
1998
Highly Cited
1998
IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts.
Subepithelial fibrosis in the bronchi of asthmatics is the result of an irreversible lung fibroblast activation, triggered by… 
Highly Cited
1997
Highly Cited
1997
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.
IL-4 receptor alpha chain (IL-4Ralpha)-deficient mice were generated by gene-targeting in BALB/c embryonic stem cells. Mutant… 
Highly Cited
1996
Highly Cited
1996
Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.
Interleukins 4 (IL-4) and 13 (IL-13) have been found previously to share receptor components on some cells, as revealed by… 
Highly Cited
1994
Highly Cited
1994
An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth
Highly Cited
1990
Highly Cited
1990
Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily
IL-4, a pleiotropic cytokine produced by T lymphocytes, plays an important role in immune responsiveness by regulating… 
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