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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose tissue chronic overnutrition leads to macrophageExpand
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Requirement for IL-13 independently of IL-4 in experimental asthma.
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralizationExpand
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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associatedExpand
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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environments. In the prevailing model ofExpand
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A promoter-level mammalian expression atlas
Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs in mammalian cell-type-specific promoters. Expand
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Interleukin-17 is a negative regulator of established allergic asthma
T helper (Th)17 cells producing interleukin (IL)-17 play a role in autoimmune and allergic inflammation. Here, we show that IL-23 induces IL-17 in the lung and IL-17 is required during antigenExpand
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Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.
Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immuneExpand
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Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages
Alternatively activated macrophages (aaMφ) display molecular and biological characteristics that differ from those of classically activated macrophages (caMφ). Recently, we described an experimentalExpand
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Control of early viral and bacterial distribution and disease by natural antibodies.
Natural antibodies are often dismissed from immunological analysis as "background," but they may play an important role in conferring immunity against infections. In antibody-free mice infected withExpand
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IL-25 regulates Th17 function in autoimmune inflammation
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 also regulates theExpand
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