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Interleukin-12

Known as: CLMF, IL12, Interleukin-12 p70 
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed… 
National Institutes of Health

Related topics

Related topics

34 relations

Broader (3)

Angiogenesis InhibitorsImmunologic Adjuvantscytokine
Cell Differentiation processCellular ImmunityChemokine CXCL10Homo sapiens

Narrower (2)

NHS-IL12 immunocytokineinterleukin-12, human recombinant

Papers overview

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Highly Cited
2008
Highly Cited
2008
S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions
Dendritic cells (DCs) are antigen-presenting cells that play an essential role in mucosal tolerance. They regularly encounter… 
Highly Cited
2002
Highly Cited
2002
The Development of Murine Plasmacytoid Dendritic Cell Precursors Is Differentially Regulated by FLT3-ligand and Granulocyte/Macrophage Colony-Stimulating Factor
Plasmacytoid predendritic cells or type 1 interferon (IFN)-producing cells (IPCs) have recently been identified in mice. Although… 
Highly Cited
2000
Highly Cited
2000
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal.
Highly Cited
1998
Highly Cited
1998
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.
Interferon-gamma receptor ligand-binding chain (IFN-gammaR1) or signaling chain (IFN-gammaR2) deficiency, like interleukin 12… 
Highly Cited
1997
Highly Cited
1997
Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.
The Epstein-Barr virus-induced gene 3 (EBI3) is a novel soluble hematopoietin component related to the p40 subunit of interleukin… 
Highly Cited
1996
Highly Cited
1996
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
Host resistance to infection by Trypanosoma cruzi is dependent on both natural and acquired immune responses. During the first… 
Highly Cited
1994
Highly Cited
1994
Impaired interleukin 12 production in human immunodeficiency virus- infected patients
Peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-infected patients, asymptomatic or with… 
Highly Cited
1991
Highly Cited
1991
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers
We previously reported that natural killer cell stimulatory factor (NKSF), a heterodimeric lymphokine purified from the… 
Highly Cited
1991
Highly Cited
1991
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
Previously we have reported the purification and characterization of a novel cytokine from an EBV-transformed B cell line, RPMI… 
Highly Cited
1990
Highly Cited
1990
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.
A cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity. The protein… 
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