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Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence
Results suggest that oxygenated mycolic acids from M. tuberculosis play a crucial role in the differentiation of macrophages into FMs, a granuloma-specific cell population characterized by its high lipid content, and could provide a relevant model for the screening of new antimicrobials against non-replicating persistent mycobacteria. Expand
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.
Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections, and mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Expand
Foamy macrophages and the progression of the human tuberculosis granuloma
The progression of tuberculosis from a latent, subclinical infection to active disease that culminates in the transmission of infectious bacilli is determined locally at the level of the granuloma, and it is indicated that pathogen-induced dysregulation of host lipid synthesis and sequestration serves a critical role in this transition. Expand
Expression cloning of a protective Leishmania antigen.
An epitope-tagged expression library was used to identify the antigen recognized by a protective CD4+ T cell clone that protected susceptible mice when administered as a vaccine with interleukin-12 before infection. Expand
The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?
The process leading to the formation of the granulomatous structures and the different cell types that have been shown to be part of this inflammatory reaction are examined. Expand
Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.
The discovery of the first discovered human disease resulting from a cytokine gene defect suggests that IL-12 is essential to and appears specific for protective immunity to intracellular bacteria such as mycobacteria and salmonella. Expand
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.
The attenuated strain of Mycobacterium bovis bacille Calmette–Guerin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it oc...
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients.
The lack of IL-12Rbeta1 expression results in a human immunodeficiency and shows the essential role in resistance to infections due to intracellular bacteria. Expand
IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.
Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-gamma are highly susceptible to mycobacteria and salmonella. Expand
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection
A hotspot for human IFNGR1 small deletions that confer dominant susceptibility to infections caused by poorly virulent mycobacteria is reported. Expand