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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restrictionExpand
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Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus
In systemic lupus erythematosus, neutrophils release peptide/self-DNA complexes that trigger plasmacytoid dendritic cell activation and autoantibody formation. Lupus Neutrophils Cast a Wide NETExpand
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Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Psoriasis is one of the most common T cell–mediated autoimmune diseases in humans. Although a role for the innate immune system in driving the autoimmune T cell cascade has been proposed, its natureExpand
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Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand
Although there is evidence for distinct roles of myeloid dendritic cells (DCs [mDCs]) and plasmacytoid pre-DCs (pDCs) in regulating T cell–mediated adaptive immunity, the concept of functional DCExpand
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Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery.
Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and control autoimmunity through aExpand
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Dendritic cell lineage, plasticity and cross-regulation
Dendritic cells (DCs) are professional antigen-presenting cells that have an extraordinary capacity to stimulate naïve T cells and initiate primary immune responses. Here we review progress inExpand
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The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.
Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide. Psoriasis is considered to be an autoimmune disease, but the precise nature of the autoantigens triggering T-cellExpand
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TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Interleukin 17–producing helper T cells (TH17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood.Expand
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Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses
  • R. Lande, M. Gilliet
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 January 2010
Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll‐like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type IExpand
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Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.
The identity of TH2 memory cells and the mechanism regulating their maintenance during allergic inflammation remain elusive. We report that circulated human CD4+ T cells expressing the prostaglandinExpand
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