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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines
- A. Edwards, S. Diebold, +5 authors C. Sousa
- Biology, MedicineEuropean journal of immunology
- 1 April 2003
It is reported that mRNA for most TLR is expressed at similar levels by murine splenic DC sub‐types, including PDC, but that TLR3 is preferentially expressed by CD8α+ DC while TLR5 and TLR7 are selectively absent from the same subset, suggesting that the dichotomy in TLR expression between plasmacytoid and non‐plasmacy toid DC is not conserved between species.
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
It is shown that dectin-1–Syk–CARD9 signaling induced DC maturation and the secretion of proinflammatory cytokines, including IL-6, tumor necrosis factor and IL-23, but little IL-12.
Toll-like receptor 3 promotes cross-priming to virus-infected cells
It is shown that murine CD8α+ dendritic cells are activated by double-stranded (ds)RNA present in virally infected cells but absent from uninfected cells, which indicates that TLR3 may have evolved to permit cross-priming of CTLs against viruses that do not directly infect dendedritic cells.
In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas
- C. Sousa, S. Hieny, +4 authors A. Sher
- Biology, MedicineThe Journal of experimental medicine
- 1 December 1997
The capacity of splenic DC but not MΦ to synthesize de novo high levels of IL-12 within hours of exposure to microbial products in vivo, as well as the ability of the same stimuli to induce migration of DC to the T cell areas, argues that DC function simultaneously as both antigen-presenting cells and IL- 12 producing accessory cells in the initiation of cell-mediated immunity to intracellular pathogens.
Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
The differences between PRR‐triggered and cytokine‐induced DC activation are reviewed and a potential role for DCs activated by inflammatory signals in tolerance induction rather than immunity is speculated on.
Dendritic cells in a mature age
- C. Sousa
- BiologyNature Reviews Immunology
- 1 June 2006
The origins of the maturation model are discussed and how terminology is evolving to better accommodate the current understanding of the function of DCs are discussed.
RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection
It is shown that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes, and nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses.
Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
The findings suggest that the unusual potency of T. gondii in inducing IL-12 from DCs results from its synthesis of a unique chemokine mimic that signals through CCR5, which may benefit parasite transmission by preventing the protozoan from overwhelming its intermediate hosts.
Myeloid C-type lectins in innate immunity
- M. Robinson, D. Sancho, E. Slack, S. Leibundgut-Landmann, C. Sousa
- Biology, MedicineNature Immunology
- 1 December 2006
This work focuses on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.