Interferon Regulatory Factors

Known as: IRF Transcription Factors, Interferon Regulatory Factors [Chemical/Ingredient], Transcription Factors, IRF 
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
0102019892017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The innate immune system recognizes nucleic acids during infection and tissue damage. Whereas viral RNA is detected by endosomal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Secretion of interferon (IFN) by virus-infected cells is essential for activating autocrine and paracrine pathways that promote… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Interferon regulatory factors (IRFs) are critical components of virus-induced immune activation and type I interferon regulation… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Dendritic cells (DC) produce interleukin-12 (IL-12) in response to Toll-like receptor (TLR) activation. Two major TLR signaling… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Recent studies implicate the interferon (IFN) regulatory factors (IRF) IRF-3 and IRF-7 as key activators of the alpha/beta IFN… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Localized and systemic cytokine production in virus-infected cells play an important role in the outcome of viral infection and… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The family of interferon regulatory factors (IRFs) plays an important role in modulating cellular responses to viral infection… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The Epstein-Barr virus (EBV) BamHI Q promoter (Qp) is the only promoter used for the transcription of Epstein-Barr virus nuclear… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?