Interferon Regulatory Factors

Known as: IRF Transcription Factors, Interferon Regulatory Factors [Chemical/Ingredient], Transcription Factors, IRF 
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
0102019892017

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14 relations

Narrower (6)

IRF5 protein, humanInterferon Regulatory Factor 8interferon regulatory factor, flounderinterferon regulatory factor-10, Gallus gallus
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In BloodProcess of secretionagonistsantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Interferon Regulatory Factors
standards characteristics
physiological aspects
chemical synthesis
IRF5 protein, human
Interferon Regulatory Factor 8

Papers overview

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Highly Cited
2008
Highly Cited
2008
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
The innate immune system recognizes nucleic acids during infection and tissue damage. Whereas viral RNA is detected by endosomal… (More)
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Highly Cited
2007
Highly Cited
2007
Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7.
Secretion of interferon (IFN) by virus-infected cells is essential for activating autocrine and paracrine pathways that promote… (More)
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Highly Cited
2005
Highly Cited
2005
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Interferon regulatory factors (IRFs) are critical components of virus-induced immune activation and type I interferon regulation… (More)
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Highly Cited
2005
Highly Cited
2005
A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
Dendritic cells (DC) produce interleukin-12 (IL-12) in response to Toll-like receptor (TLR) activation. Two major TLR signaling… (More)
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Highly Cited
2003
Highly Cited
2003
Triggering the interferon antiviral response through an IKK-related pathway.
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires… (More)
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Highly Cited
2000
Highly Cited
2000
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.
Recent studies implicate the interferon (IFN) regulatory factors (IRF) IRF-3 and IRF-7 as key activators of the alpha/beta IFN… (More)
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Highly Cited
1999
Highly Cited
1999
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.
Localized and systemic cytokine production in virus-infected cells play an important role in the outcome of viral infection and… (More)
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Highly Cited
1998
Highly Cited
1998
Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes.
The family of interferon regulatory factors (IRFs) plays an important role in modulating cellular responses to viral infection… (More)
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Highly Cited
1998
Highly Cited
1998
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
The interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as… (More)
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Highly Cited
1997
Highly Cited
1997
IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency.
The Epstein-Barr virus (EBV) BamHI Q promoter (Qp) is the only promoter used for the transcription of Epstein-Barr virus nuclear… (More)
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