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Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression*
Both activating and null mutations of proteins required for canonical WNT signaling have revealed the importance of this pathway for normal skeletal development. However, tissue-specificExpand
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A microRNA signature for a BMP2-induced osteoblast lineage commitment program
Bone morphogenetic proteins (BMPs) are potent morphogens that activate transcriptional programs for lineage determination. How BMP induction of a phenotype is coordinated with microRNAs (miRNAs) thatExpand
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Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase
Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study weExpand
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Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone in the adult involve an exquisite interplay of developmental cues, signaling proteins, transcription factors,Expand
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A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
  • Y. Zhang, R. Xie, +4 authors G. Stein
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 31 May 2011
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate–determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs)Expand
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Networks and hubs for the transcriptional control of osteoblastogenesis
We present an overview of the concepts of tissue-specific transcriptional control mechanisms essential for development of the bone cell phenotype. BMP2 induced transcription factors constitute aExpand
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MicroRNA control of bone formation and homeostasis
MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of gene regulation that coordinates a broad spectrum of biological processes. Bone organogenesis is a complexExpand
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Tyrosine phosphorylation controls Runx2‐mediated subnuclear targeting of YAP to repress transcription
Src/Yes tyrosine kinase signaling contributes to the regulation of bone homeostasis and inhibits osteoblast activity. Here we show that the endogenous Yes‐associated protein (YAP), a mediator ofExpand
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The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion
ABSTRACT The Runx2 (Cbfa1/AML3) transcription factor and matrix metalloproteinase 9 (MMP9) are key regulators of growth plate maturation and bone formation. The genes for both proteins areExpand
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Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation*
Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling cascades. MicroRNAs regulate biological processes by binding to mRNAExpand
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