IRF5 protein, human

Known as: IRF-5, interferon regulatory factor-5 protein, human, IRF-5 protein, human 
Interferon regulatory factor 5 (498 aa, ~56 kDa) is encoded by the human IRF5 gene. This protein is involved in the modulation of pro-inflammatory… (More)
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
OBJECTIVES The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5… (More)
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Highly Cited
2011
Highly Cited
2011
Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many… (More)
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Highly Cited
2009
Highly Cited
2009
While the recognition of microbial infection often occurs at the cell surface via Toll-like receptors, the cytosol of the cell is… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE A haplotype of the interferon regulatory factor 5 (IRF5) gene has been associated with the risk of developing systemic… (More)
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Highly Cited
2007
Highly Cited
2007
Systematic genome-wide studies to map genomic regions associated with human diseases are becoming more practical. Increasingly… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Interferon regulatory factor 5 (IRF-5) is a transcription factor involved in the regulation of the host defense… (More)
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Highly Cited
2007
Highly Cited
2007
Results from two studies have implicated the interferon regulatory gene IRF5 as a susceptibility gene in systemic lupus… (More)
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Highly Cited
2006
Highly Cited
2006
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by activation of the type I interferon (IFN… (More)
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Highly Cited
2005
Highly Cited
2005
The activation of Toll-like receptors (TLRs) is central to innate and adaptive immunity. All TLRs use the adaptor MyD88 for… (More)
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Highly Cited
2004
Highly Cited
2004
In humans, the type I interferon (IFN) family consists of 13 IFN-alpha subtypes, IFN-beta and IFN-omicron the newly discovered… (More)
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