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IRF5 protein, human

Known as: IRF-5, interferon regulatory factor-5 protein, human, IRF-5 protein, human 
Interferon regulatory factor 5 (498 aa, ~56 kDa) is encoded by the human IRF5 gene. This protein is involved in the modulation of pro-inflammatory… 
National Institutes of Health

Related topics

Related topics

10 relations
Antiviral ResponseDNA-Binding ProteinsGenes, RegulatorIRF5 gene

Broader (1)

Interferon Regulatory Factors

Papers overview

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Highly Cited
2015
Highly Cited
2015
Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity
Accumulation of visceral adipose tissue correlates with elevated inflammation and increased risk of metabolic diseases. However… 
Highly Cited
2013
Highly Cited
2013
IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I interferon (IFN) induction and IFN… 
Highly Cited
2011
Highly Cited
2011
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
Objective High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto… 
Highly Cited
2010
Highly Cited
2010
IRF5 is required for late-phase TNF secretion by human dendritic cells.
Spatially and temporally controlled expression of inflammatory mediators is critical for an appropriate immune response. In this… 
Highly Cited
2009
Highly Cited
2009
Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis.
OBJECTIVE There is now growing evidence that connective tissue diseases, including systemic sclerosis (SSc), share a common… 
Highly Cited
2008
Highly Cited
2008
Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.
OBJECTIVE A haplotype of the interferon regulatory factor 5 (IRF5) gene has been associated with the risk of developing systemic… 
Highly Cited
2005
Highly Cited
2005
Negative regulation of Toll-like-receptor signaling by IRF-4.
The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and… 
Highly Cited
2004
Highly Cited
2004
Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral Infection*
The interferon regulatory factors (IRF) are transcriptional mediators of cellular response to viral invasion that play a critical… 
Highly Cited
2003
Highly Cited
2003
Virus-induced Heterodimer Formation betweenIRF-5 and IRF-7 Modulates Assembly of theIFNA Enhanceosome in Vivo and Transcriptional Activity of IFNA Genes*
Transcription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early… 
Highly Cited
2002
Highly Cited
2002
Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T Lymphocytes
ABSTRACT Transcription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of… 
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