Negative regulation of Toll-like-receptor signaling by IRF-4.

  title={Negative regulation of Toll-like-receptor signaling by IRF-4.},
  author={Hideo Negishi and Yusuke Ohba and Hideyuki Yanai and Akinori Takaoka and Kiri Honma and Katsuyuki Yui and Toshifumi Matsuyama and T. Taniguchi and Kenya Honda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 44},
The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of downstream target genes, wherein the TLR-interacting adaptor molecule MyD88 recruits various signaling molecules and transcription factors. Two members of the IFN regulatory factor (IRF) family of transcription factors, IRF-5 and IRF-7, interact with MyD88 and induce proinflammatory cytokines and type I IFNs… CONTINUE READING